Challenges and limitations of patient-specific vascular phantom fabrication using 3D Polyjet printing.
Challenges and limitations of patient-specific vascular phantom fabrication using 3D Polyjet printing.
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DOI：
10.1117/12.2042266
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发表时间：
2014-03-13
期刊：
影响因子：
--
通讯作者：
Rudin S
中科院分区：
文献类型：
--
作者：
Ionita CN;Mokin M;Varble N;Bednarek DR;Xiang J;Snyder KV;Siddiqui AH;Levy EI;Meng H;Rudin S
增材制造（3D打印）技术为开发患者特定的血管解剖模型提供了巨大的机会，用于医疗器械测试和生理状况评估。然而，开发过程还没有很好地建立起来，并且根据打印材料、技术和打印机分辨率存在各种限制。通过计算机断层扫描血管造影术和旋转数字减影血管造影术（DSA）获取患者特定的神经血管解剖结构。将体积导入Vitrea 3D工作站（Vital Images Inc.）并且使用“行进立方体”算法分割各种血管和病变的血管腔。将结果导出为立体光刻（STL）文件，并通过平滑、修剪和壁挤出（向模型添加自定义壁）进行进一步处理。使用Polyjet打印机Eden 260 V（Objet-Stratasys）打印模型。为了验证体模几何结构的准确性，使用旋转DSA对体模进行重新成像，并将新数据与初始患者数据进行比较。体模制造中最具挑战性的部分是去除支撑材料。这方面可能是一个严重的障碍，在建设非常曲折的幻影或小血管。打印模型的准确性非常好：距离分析显示患者和体模重建体积尺寸之间的平均差异为120 μm。大多数错误是由于残留的支撑材料留在体模的管腔中。尽管在支架清洁过程中遇到了打印后的挑战，但这项技术可能会为医疗研究带来巨大的好处，例如设备开发和测试。
Additive manufacturing (3D printing) technology offers a great opportunity towards development of patient-specific vascular anatomic models, for medical device testing and physiological condition evaluation. However, the development process is not yet well established and there are various limitations depending on the printing materials, the technology and the printer resolution. Patient-specific neuro-vascular anatomy was acquired from computed tomography angiography and rotational digital subtraction angiography (DSA). The volumes were imported into a Vitrea 3D workstation (Vital Images Inc.) and the vascular lumen of various vessels and pathologies were segmented using a “marching cubes” algorithm. The results were exported as Stereo Lithographic (STL) files and were further processed by smoothing, trimming, and wall extrusion (to add a custom wall to the model). The models were printed using a Polyjet printer, Eden 260V (Objet-Stratasys). To verify the phantom geometry accuracy, the phantom was reimaged using rotational DSA, and the new data was compared with the initial patient data. The most challenging part of the phantom manufacturing was removal of support material. This aspect could be a serious hurdle in building very tortuous phantoms or small vessels. The accuracy of the printed models was very good: distance analysis showed average differences of 120 μm between the patient and the phantom reconstructed volume dimensions. Most errors were due to residual support material left in the lumen of the phantom. Despite the post-printing challenges experienced during the support cleaning, this technology could be a tremendous benefit to medical research such as in device development and testing.
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影响因子：
3.8
作者：
Allard, Louise;Soulez, Gilles;Cloutier, Guy
通讯作者：
Cloutier, Guy
影响因子：
2.6
作者：
Hayes, Paul D.;Sadat, Umar;Boyle, Jonathan R.
通讯作者：
Boyle, Jonathan R.
影响因子：
3.8
作者：
Schafer, Sebastian;Hoffmann, Kenneth R.;Dmochowski, Jacek
通讯作者：
Dmochowski, Jacek
影响因子：
37.8
作者：
Go AS;Mozaffarian D;Roger VL;Benjamin EJ;Berry JD;Borden WB;Bravata DM;Dai S;Ford ES;Fox CS;Franco S;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Huffman MD;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Magid D;Marcus GM;Marelli A;Matchar DB;McGuire DK;Mohler ER;Moy CS;Mussolino ME;Nichol G;Paynter NP;Schreiner PJ;Sorlie PD;Stein J;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
影响因子：
3.5
作者：
Cebral, J. R.;Mut, F.;Putman, C. M.
通讯作者：
Putman, C. M.