Hypertriglyceridemia: A Neglected Risk Factor for Ischemic Stroke?

Hypertriglyceridemia: A Neglected Risk Factor for Ischemic Stroke?
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DOI:
10.5853/jos.2021.02831
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发表时间:
2022-01
期刊:
影响因子:
8.2
通讯作者:
Qi R
Qi R
中科院分区:
医学2区
文献类型:
--
作者:
Liang HJ;Zhang QY;Hu YT;Liu GQ;Qi R

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高甘油三酯血症是由甘油三酯代谢缺陷引起的,通常表现为异常高的血浆甘油三酯水平。虽然高甘油三酯血症在卒中中的作用可能不如血浆胆固醇引起那么多的关注,但血浆甘油三酯,尤其是非空腹甘油三酯,被认为与缺血性卒中的风险相关。高甘油三酯血症可能通过促进动脉粥样硬化和血栓形成以及增加血液粘度而增加缺血性卒中的风险。此外,高胆固醇血症可能通过不清楚的机制对已经遭受中风的患者具有一些保护作用。因此,需要进一步的研究来阐明高胆固醇血症在缺血性脑卒中的发展和预后中的作用。
Hypertriglyceridemia is caused by defects in triglyceride metabolism and generally manifests as abnormally high plasma triglyceride levels. Although the role of hypertriglyceridemia may not draw as much attention as that of plasma cholesterol in stroke, plasma triglycerides, especially nonfasting triglycerides, are thought to be correlated with the risk of ischemic stroke. Hypertriglyceridemia may increase the risk of ischemic stroke by promoting atherosclerosis and thrombosis and increasing blood viscosity. Moreover, hypertriglyceridemia may have some protective effects in patients who have already suffered a stroke via unclear mechanisms. Therefore, further studies are needed to elucidate the role of hypertriglyceridemia in the development and prognosis of ischemic stroke.
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