Facile preparation of succinylated-zein-ZIF-8 hybrid for enhanced stability and pH-responsive drug delivery
Facile preparation of succinylated-zein-ZIF-8 hybrid for enhanced stability and pH-responsive drug delivery
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轻松制备琥珀酰化-玉米醇溶蛋白-ZIF-8 杂化物，以增强稳定性和 pH 响应性药物递送
DOI：
10.1016/j.ces.2020.115981
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发表时间：
2020-07
影响因子：
4.7
通讯作者：
Jiang Yanbin
中科院分区：
文献类型：
--
作者：
Zhu Wei;Huang Wenquan;Ye Liping;Deng Yuehua;Xie Qiuling;Jiang Yanbin
Zein nanoparticles have good prospects as a pharmaceutical carrier but limited in further application by its poor stability and re-dispersibility. To obtain high stability and pH-responsive drug delivery, succinylated-zein (Suc-zein) was synthesized by nucleophilic substitution reaction, the material obtained was used to prepare Suc-zein nanoparticles (SZs). The SZs prepared not only had good dispersibility but showed better stability than zein particles on pH, storage and salinity. After loading indomethacin (Indo) into zeolitic imidazolate framework-8 (ZIF-8), the core-shelled Indo-Suc-zein-ZIF-8 (Indo-SZZs) were fabricated by coating Suc-zein onto the surface of ZIF-8 with better stability and high drug loading. Indo-SZZs were pH-responsive and sustained a drug release profile in a simulated environment. Also SZZs presented as being non-toxic, having good biocompatibility and good cellular up-take performance, and the cytotoxicity of Indo-SZZs was significantly higher than that of Indo. This provides a new insight into the preparation of a zein-based oral drug delivery system.
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影响因子：
10.2
作者：
Regier MC;Taylor JD;Borcyk T;Yang Y;Pannier AK
通讯作者：
Pannier AK
影响因子：
15.1
作者：
Guijin Liu;W. Wang;Hongdi Wang;Yanbin Jiang
通讯作者：
Guijin Liu;W. Wang;Hongdi Wang;Yanbin Jiang
用于多酚输送系统的具有稳定和自我抗氧化特性的聚多巴胺介导的载体
影响因子：
4.2
作者：
Li Shaomin;Li Zhixian;Pang Jiafeng;Chen Jing;Wang Hongdi;Xie Qiuling;Jiang Yanbin
通讯作者：
Jiang Yanbin
影响因子：
3.4
作者：
Malingré, MM;Beijnen, JH;Schellens, JHM
通讯作者：
Schellens, JHM
影响因子：
10.8
作者：
Chauhan, AS;Sridevi, S;Diwan, PV
通讯作者：
Diwan, PV