High-frequency oscillations: The state of clinical research.
High-frequency oscillations: The state of clinical research.
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作者：
Frauscher B;Bartolomei F;Kobayashi K;Cimbalnik J;van 't Klooster MA;Rampp S;Otsubo H;Höller Y;Wu JY;Asano E;Engel J Jr;Kahane P;Jacobs J;Gotman J
现代脑电(EEG)技术有助于认识到经典Berger频段以外的EEG信号包含重要信息。在癫痫方面，过去十年的研究特别集中在发作间期高频振荡(HFO)和80赫兹。HFOS的第一次大规模应用是在癫痫手术的背景下。现在紧随其后的是其他应用，如癫痫严重程度的评估和抗癫痫治疗的监测。本文综述了HFO临床应用于癫痫的证据，重点介绍了最新的研究进展。它强调了越来越多的文献关于HFO和手术后癫痫结果之间的联系。最近的一项荟萃分析证实，无癫痫发作的患者与无癫痫发作的患者相比，HFO的切除率更高。术后皮质脑电图中残留的HFO比术前HFO比率更好地预测癫痫手术结果。该综述进一步讨论了将生理性HFO与癫痫HFO分开的不同尝试，因为这可能增加HFO的特异性。例如，对睡眠微结构的分析表明，在致痫区域内外，高频电波之间存在不同的耦合。此外，越来越多的证据表明，利用非侵入性脑电和脑磁图，HFO可用于测量疾病活动性和评估治疗反应。这种方法在儿童中特别有希望，因为他们表现出很高的头皮HFO发生率。经促肾上腺皮质激素治疗后，West综合征的HFO发生率降低。在罗兰迪峰出现时，HFO的存在与癫痫发作频率相关。过去阻碍了HFO临床应用的耗时的视觉评估，现在被有效的计算机辅助算法克服了。在过去的十年中，HFO的研究取得了相当大的进步，使用非侵入性方法将使大量患者能够接触到HFO。预期的多中心试验将在较长的记录期内收集大量患者样本的信息。
Modern electroencephalographic (EEG) technology contributed to the appreciation that the EEG signal outside the classical Berger frequency band contains important information. In epilepsy, research of the past decade focused particularly on interictal high-frequency oscillations (HFOs) > 80 Hz. The first large application of HFOs was in the context of epilepsy surgery. This is now followed by other applications such as assessment of epilepsy severity and monitoring of antiepileptic therapy. This article reviews the evidence on the clinical use of HFOs in epilepsy with an emphasis on the latest developments. It highlights the growing literature on the association between HFOs and post-surgical seizure outcome. A recent meta-analysis confirmed a higher resection ratio for HFOs in seizure-free versus non–seizure-free patients. Residual HFOs in the postoperative electrocorticogram were shown to predict epilepsy surgery outcome better than preoperative HFO rates. The review further discusses the different attempts to separate physiological from epileptic HFOs, as this might increase the specificity of HFOs. As an example, analysis of sleep microstructure demonstrated a different coupling between HFOs inside and outside the epileptogenic zone. Moreover, there is increasing evidence that HFOs are useful to measure disease activity and assess treatment response using noninvasive EEG and magnetoencephalography. This approach is particularly promising in children, because they show high scalp HFO rates. HFO rates in West syndrome decrease after adrenocorticotropic hormone treatment. Presence of HFOs at the time of rolandic spikes correlates with seizure frequency. The time-consuming visual assessment of HFOs, which prevented their clinical application in the past, is now overcome by validated computer-assisted algorithms. HFO research has considerably advanced over the past decade, and use of noninvasive methods will make HFOs accessible to large numbers of patients. Prospective multicenter trials are awaited to gather information over long recording periods in large patient samples.
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影响因子：
5.6
作者：
Bragin, A;Wilson, CL;Engel, T
通讯作者：
Engel, T
影响因子：
5.6
作者：
Fujiwara H;Greiner HM;Lee KH;Holland-Bouley KD;Seo JH;Arthur T;Mangano FT;Leach JL;Rose DF
通讯作者：
Rose DF
影响因子：
5.6
作者：
Akiyama, Tomoyuki;Chan, Derrick W.;Otsubo, Hiroshi
通讯作者：
Otsubo, Hiroshi
影响因子：
2.7
作者：
Andrzejak, Ralph G.;David, Olivier;de Curtis, Marco
通讯作者：
de Curtis, Marco
DOI：
10.1093/brain/awv073
发表时间：
2015-06
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Frauscher B;von Ellenrieder N;Ferrari-Marinho T;Avoli M;Dubeau F;Gotman J
通讯作者：
Gotman J