Coronavirus Disease 2019-Associated Invasive Fungal Infection.
Coronavirus Disease 2019-Associated Invasive Fungal Infection.
复制标题
DOI：
10.1093/ofid/ofab510
复制
发表时间：
2021-12
影响因子：
4.2
通讯作者：
Pappas PG
中科院分区：
文献类型：
--
作者：
Baddley JW;Thompson GR 3rd;Chen SC;White PL;Johnson MD;Nguyen MH;Schwartz IS;Spec A;Ostrosky-Zeichner L;Jackson BR;Patterson TF;Pappas PG
2019冠状病毒病（COVID-19）可因继发性侵袭性真菌感染（IFIs）而变得复杂，这主要是由与病毒或免疫调节治疗相关的严重肺损伤和免疫缺陷引起的。其他危险因素包括控制不良的糖尿病、结构性肺病和/或其他合并症，以及真菌定植。严重呼吸道病毒性疾病后的机会性IFI已得到越来越多的认识，最明显的是严重流感。已有许多与COVID-19相关的真菌感染报告，最初以肺曲霉病为主，但最近出现了毛霉病、念珠菌病和地方性真菌病。这些感染可能很难诊断，并与不良后果有关。报告的IFI发病率各不相同，通常与患者群体的异质性、监测方案和用于真菌感染分类的定义有关。在此，我们回顾了IFI与COVID-19合并的情况，并解决了与COVID-19相关真菌感染的流行病学、诊断和管理相关的知识空白。
Coronavirus disease 2019 (COVID-19) can become complicated by secondary invasive fungal infections (IFIs), stemming primarily from severe lung damage and immunologic deficits associated with the virus or immunomodulatory therapy. Other risk factors include poorly controlled diabetes, structural lung disease and/or other comorbidities, and fungal colonization. Opportunistic IFI following severe respiratory viral illness has been increasingly recognized, most notably with severe influenza. There have been many reports of fungal infections associated with COVID-19, initially predominated by pulmonary aspergillosis, but with recent emergence of mucormycosis, candidiasis, and endemic mycoses. These infections can be challenging to diagnose and are associated with poor outcomes. The reported incidence of IFI has varied, often related to heterogeneity in patient populations, surveillance protocols, and definitions used for classification of fungal infections. Herein, we review IFI complicating COVID-19 and address knowledge gaps related to epidemiology, diagnosis, and management of COVID-19–associated fungal infections.
登录
查看更多内容
影响因子：
9.4
作者：
Borman AM;Palmer MD;Fraser M;Patterson Z;Mann C;Oliver D;Linton CJ;Gough M;Brown P;Dzietczyk A;Hedley M;McLachlan S;King J;Johnson EM
通讯作者：
Johnson EM
DOI：
10.3390/pathogens10020157
发表时间：
2021-02-03
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
Allaw F;Kara Zahreddine N;Ibrahim A;Tannous J;Taleb H;Bizri AR;Dbaibo G;Kanj SS
通讯作者：
Kanj SS
影响因子：
5.5
作者：
Basso RP;Poester VR;Benelli JL;Stevens DA;Zogbi HE;Vasconcellos ICDS;Pasqualotto AC;Xavier MO
通讯作者：
Xavier MO
DOI：
10.1177/2324709620972244
发表时间：
2020-01
影响因子：
1.2
作者：
Chang CC;Senining R;Kim J;Goyal R
通讯作者：
Goyal R
影响因子：
11.8
作者：
Chapman, Stanley W.;Dismukes, William E.;Kauffman, Carol A.
通讯作者：
Kauffman, Carol A.