The Effect of CO(2) on Resting-State Functional Connectivity: Isocapnia vs. Poikilocapnia.
The Effect of CO(2) on Resting-State Functional Connectivity: Isocapnia vs. Poikilocapnia.
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DOI：
10.3389/fphys.2021.639782
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发表时间：
2021
影响因子：
4
通讯作者：
Mikulis DJ
中科院分区：
文献类型：
--
作者：
McKetton L;Sam K;Poublanc J;Crawley AP;Sobczyk O;Venkatraghavan L;Duffin J;Fisher JA;Mikulis DJ
呼吸大小和频率的正常变异性导致潮气末PCO 2（PETCO 2）（测量变量）和动脉二氧化碳分压（PaCO 2）（影响脑血流量（CBF）的自变量）的呼吸间变异性。本研究探讨了PaCO 2的变化对静息态功能性MRI（rs-fMRI）连接模式的影响。在两种静息状态条件下进行感兴趣区（ROI）-ROI和种子-体素一级双变量相关性、血流动力学反应函数（hrf）-加权分析，以测量rs-fMRI连接性：（a）与PaCO 2呼吸间变化相关的正常呼吸（血碳酸血症），和（B）使用顺序再呼吸抑制PETCO 2呼吸间变化的正常呼吸（血碳酸血症）。呼气末PCO 2（PETCO 2）被用作PaCO 2波动的可测量替代物。在POIKILOCANIA期间，发现小脑与额下回和缘上回（SG），视觉皮层和枕梭状回之间以及初级视觉网络（PVN）与海马结构之间的功能连接增强。在等碳酸血症期间，未观察到这些关联，而是在壳核和距核内皮质、距核上皮质（SCC）和楔前叶皮质之间的皮质纹状体通路中发现了增强的功能连接。我们的结论是，血管反应的变化PETCO 2，占至少有一些观察到的静息状态同步血氧水平依赖（BOLD）信号。
The normal variability in breath size and frequency results in breath-to-breath variability of end-tidal PCO2 (PETCO2), the measured variable, and arterial partial pressure of carbon dioxide (PaCO2), the independent variable affecting cerebral blood flow (CBF). This study examines the effect of variability in PaCO2 on the pattern of resting-state functional MRI (rs-fMRI) connectivity. A region of interest (ROI)-to-ROI and Seed-to-Voxel first-level bivariate correlation, hemodynamic response function (hrf)-weighted analysis for measuring rs-fMRI connectivity was performed during two resting-state conditions: (a) normal breathing associated with breath-to-breath variation in PaCO2 (poikilocapnia), and (b) normal breathing with breath-to-breath variability of PETCO2 dampened using sequential rebreathing (isocapnia). End-tidal PCO2 (PETCO2) was used as a measurable surrogate for fluctuations of PaCO2. During poikilocapnia, enhanced functional connections were found between the cerebellum and inferior frontal and supramarginal gyrus (SG), visual cortex and occipital fusiform gyrus; and between the primary visual network (PVN) and the hippocampal formation. During isocapnia, these associations were not seen, rather enhanced functional connections were identified in the corticostriatal pathway between the putamen and intracalacarine cortex, supracalcarine cortex (SCC), and precuneus cortex. We conclude that vascular responses to variations in PETCO2, account for at least some of the observed resting state synchronization of blood oxygenation level-dependent (BOLD) signals.
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