Altered patterns of migration of cytokine‐producing T lymphocytes in skin‐grafted naive or immune mice following in vivo administration of anti‐VCAM‐1 or ‐ICAM‐1
Altered patterns of migration of cytokine‐producing T lymphocytes in skin‐grafted naive or immune mice following in vivo administration of anti‐VCAM‐1 or ‐ICAM‐1
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体内给予抗VCAM-1或-ICAM-1后，移植皮肤的幼鼠或免疫小鼠中产生细胞因子的T淋巴细胞迁移模式的改变
DOI：
10.1046/j.1365-2567.1996.511581.x
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发表时间：
1996
期刊：
影响因子：
6.4
通讯作者：
Z. Chen
中科院分区：
文献类型：
--
作者：
R. Gorczynski;S. Chung;Y. Hoang;B. Sullivan;Z. Chen
Naive or preimmunized (to B10.BR or BALB.k) C3H/HeJ mice received skin grafts from multiple minor histoincompatible B10.BR or BALB.k mice following antigen‐specific portal venous (p.v.) pretransplant transfusion, a protocol known to produce prolongation of graft survival in naive animals. In addition, groups of mice received intravenous (i.v.) infusion following transplantation with a mixture of monoclonal antibodies (mAb) to vascular adhesion molecule‐1L : very late activation antigen‐4 (VCAM‐1 : VLA‐4) or intracellular adhesion molecule‐1 : lymphocyte function‐associated antigen‐3 (ICAM‐1 : LFA‐1). Cells were harvested from different tissues of the grafted mice at various times post grafting. RNA was extracted and analysed, using polymerase chain reaction, for expression of different cytokines potentially involved in the regulation of graft rejection [interleukin‐2 (IL‐2), IL‐4, IL‐6, IL‐10, tumour necrosis factor‐α, interferon‐γ and transforming growth factor‐β]. In addition, using limiting dilution analysis, we investigated the frequency of allo‐specific and third‐party reactive cells producing IL‐2 and IL‐4 in vitro in different tissues of grafted mice following these treatments. The mAb treatment protocol which produced optimum increases in graft survival in naive versus immune mice was different, with anti‐LFA‐1 : ICAM‐1 superior for naive mice compared with anti‐VLA‐4 : VCAM‐1, and vice versa for immune animals. However, in each case, increased survival was associated with increases local to the graft in the frequency of occurrence of antigen‐specific type‐2 cytokine‐producing cells.
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影响因子：
2.7
作者：
S. Kamdar;R. Evans
通讯作者：
S. Kamdar;R. Evans
大鼠体内 CD4 T 细胞功能异质性的证据。
DOI：
--
发表时间：
1992
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Papp,I;Wieder,KJ;Sablinski,T;O'Connell,PJ;Milford,EL;Strom,TB;Kupiec-Weglinski,JW
通讯作者：
Kupiec-Weglinski,JW
组织特异性归巢受体介导淋巴细胞粘附到细胞因子刺激的淋巴结高内皮小静脉细胞。
影响因子：
6.4
作者：
Chin,YH;Cai,JP;Xu,XM
通讯作者：
Xu,XM
影响因子：
4.4
作者：
M. Jenkins;P. Taylor;S. Norton;K. Urdahl
通讯作者：
M. Jenkins;P. Taylor;S. Norton;K. Urdahl
人同种异体肝移植物中浸润性 T 淋巴细胞的功能特征。
影响因子：
2.7
作者：
Fung,JJ;Zeevi,A;Starzl,TE;Demetris,J;Iwatsuki,S;Duquesnoy,RJ
通讯作者：
Duquesnoy,RJ