Differential effects of laparoscopic sleeve gastrectomy and laparoscopic gastric bypass on appetite, circulating acyl-ghrelin, peptide YY3-36 and active GLP-1 levels in non-diabetic humans.
Differential effects of laparoscopic sleeve gastrectomy and laparoscopic gastric bypass on appetite, circulating acyl-ghrelin, peptide YY3-36 and active GLP-1 levels in non-diabetic humans.
复制标题
腹腔镜套筒胃切除术和腹腔镜胃搭桥对食欲，循环酰基 - ghrelin，肽YY3-36和活性GLP-1水平的差异作用。
DOI：
10.1007/s11695-013-1066-0
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发表时间：
2014-02
期刊：
影响因子：
2.9
通讯作者：
Batterham, Rachel L.
中科院分区：
文献类型：
--
作者：
Yousseif, Ahmed;Emmanuel, Julian;Karra, Efthimia;Millet, Queensta;Elkalaawy, Mohamed;Jenkinson, Andrew D.;Hashemi, Majid;Adamo, Marco;Finer, Nicholas;Fiennes, Alberic G.;Withers, Dominic J.;Batterham, Rachel L.
关键词：
Laparoscopic Roux-en-Y gastric bypass (LRYGBP) reduces appetite and induces significant and sustainable weight loss. Circulating gut hormones changes engendered by LRYGBP are implicated in mediating these beneficial effects. Laparoscopic sleeve gastrectomy (LSG) is advocated as an alternative to LRYGBP, with comparable short-term weight loss and metabolic outcomes. LRYGBP and LSG are anatomically distinct procedures causing differential entero-endocrine cell nutrient exposure and thus potentially different gut hormone changes. Studies reporting the comparative effects of LRYGBP and LSG on appetite and circulating gut hormones are controversial, with no data to date on the effects of LSG on circulating peptide YY3-36 (PYY3-36) levels, the specific PYY anorectic isoform. In this study, we prospectively investigated appetite and gut hormone changes in response to LRYGBP and LSG in adiposity-matched non-diabetic patients. Anthropometric indices, leptin, fasted and nutrient-stimulated acyl-ghrelin, active glucagon-like peptide-1 (GLP-1), PYY3-36 levels and appetite were determined pre-operatively and at 6 and 12 weeks post-operatively in obese, non-diabetic females, with ten undergoing LRYGBP and eight adiposity-matched females undergoing LSG. LRYGBP and LSG comparably reduced adiposity. LSG decreased fasting and post-prandial plasma acyl-ghrelin compared to pre-surgery and to LRYGBP. Nutrient-stimulated PYY3-36 and active GLP-1 concentrations increased post-operatively in both groups. However, LRYGBP induced greater, more sustained PYY3-36 and active GLP-1 increments compared to LSG. LRYGBP suppressed fasting hunger compared to LSG. A similar increase in post-prandial fullness was observed post-surgery following both procedures. LRYGBP and LSG produced comparable enhanced satiety and weight loss. However, LSG and LRYGBP differentially altered gut hormone profiles.
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影响因子：
82.9
作者：
通讯作者：
--
影响因子：
5.8
作者：
Falken, Y.;Hellstrom, P. M.;Naslund, E.
通讯作者：
Naslund, E.
影响因子：
5.8
作者：
Katsuki, A;Urakawa, H;Sumida, Y
通讯作者：
Sumida, Y
DOI：
10.1016/j.jamcollsurg.2011.09.006
发表时间：
2011-12-01
影响因子：
5.2
作者：
Gould, Jon C.;Kent, K. Craig;Campos, Guilherme M.
通讯作者：
Campos, Guilherme M.
影响因子：
9
作者：
Karamanakos, Stavros N.;Vagenas, Konstantinos;Alexandrides, Theodore K.
通讯作者：
Alexandrides, Theodore K.