Hyperuricemia is associated with atrial fibrillation prevalence in very elderly - a community based study in Chengdu, China.
Hyperuricemia is associated with atrial fibrillation prevalence in very elderly - a community based study in Chengdu, China.
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DOI：
10.1038/s41598-018-30321-z
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发表时间：
2018-08-17
影响因子：
4.6
通讯作者：
Zhang TJ
中科院分区：
文献类型：
--
作者：
Huang G;Xu RH;Xu JB;Liu Y;Liu ZH;Xie X;Zhang TJ
高尿酸血症是心血管疾病的危险因素。然而，在高龄患者中，高尿酸血症与房颤（AF）患病率之间的关系尚不清楚。本研究旨在探讨社区高龄老人高尿酸血症与房颤的关系。在这项横断面研究中，1056名社区高龄老人被纳入。测定血尿酸（SUA），并进行静息12导联心电图检查。采用多因素Logistic回归模型探讨高龄患者房颤的危险因素。最后，1038名参与者被纳入分析，研究参与者的平均年龄为83.6 ± 3.4岁（年龄范围80-100岁）。平均SUA水平为350.1 ± 84.5 µmol/L。AF的估计患病率为5.3%，无显著性别差异（男性为5.8%，女性为4.8%，p = 0.401）。多因素logistic回归分析发现，在中国老年人中，高尿酸血症（男性SUA >416 µmol/L，女性>357 µmol/L）患者发生AF的风险较高（比值比：2.080，95%置信区间：1.103-4.202，P = 0.007）。总之，房颤在成都市老年人群中相对较常见。高尿酸血症通常与高龄房颤的患病率相关。
Hyperuricemia is a risk factor for cardiovascular diseases. However, in very elderly, the relationship between hyperuricemia and the prevalence of atrial fibrillation (AF) is not clear. This study aimed to investigate hyperuricemia and the risk of AF in community very elderly. In this cross-sectional study, 1056 very elderly in community were enrolled. Serum uric acid (SUA) were measured and rest 12-lead electrocardiogram was performed. Multiple logistic regression models were used to explore risk factors for AF in very elderly. Finally, 1038 participants were included in analysis and the mean age of the study participants were 83.6 ± 3.4 years (age range 80–100 years). The mean SUA level was 350.1 ± 84.5 µmol/L. The estimated prevalence of AF was 5.3%, and there was no significant sex difference (5.8% for men and 4.8% for women, p = 0.401). Multiple logistic regression found that participants with hyperuricemia (SUA >416 µmol/L in men and >357 µmol/L in women) had a higher risk (odds ratio: 2.080, 95% confidence interval: 1.103–4.202, P = 0.007) of suffering AF in very elderly Chinese. In conclusion, AF is relatively frequent in this community very elderly Chinese in Chengdu. Hyperuricemia is associated with the prevalence of AF in general very elderly.
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影响因子：
4.6
作者：
Li M;Hu X;Fan Y;Li K;Zhang X;Hou W;Tang Z
通讯作者：
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影响因子：
7.4
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通讯作者：
Lip, Gregory Y. H.
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1.2
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通讯作者：
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作者：
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通讯作者：
KANNEL, WB