Adenosine modulation of striatal neurotransmitter release monitored in vivo using voltammetry
Adenosine modulation of striatal neurotransmitter release monitored in vivo using voltammetry
复制标题
使用伏安法监测体内纹状体神经递质释放的腺苷调节
DOI：
10.1016/0304-3940(86)90004-2
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发表时间：
1986
影响因子：
2.5
通讯作者：
R. O'Neill
中科院分区：
文献类型：
--
作者：
R. O'Neill
用碳糊电极线性扫描伏安法同步记录未麻醉大鼠纹状体细胞外抗坏血酸、尿酸和高香草酸(HVA)浓度的变化。抗坏血酸信号被用作兴奋性氨基酸释放的指标，而HVA信号反映了多巴胺释放的变化。微量注射2-氯腺苷抑制抗坏血酸和HVA信号，注入腺苷脱氨酶则增加这两种信号的幅度。根据损伤+结合研究，这些结果表明，内源性腺苷的释放可能调节皮质纹状体和黑质纹状体终末的递质释放。腺苷脱氨酶对尿酸盐信号的影响提供了初步证据，表明该信号的变化可能反映了腺苷释放的变化。
Linear sweep voltammetry with carbon-paste electrodes was used to record simultaneously changes in the extracellular concentration of ascorbic acid, uric acid and homovanillic acid (HVA) in the striatum of unanaesthetized rats. The ascorbate signal was used as an index of excitatory amino acid release, whereas the HVA signal reflects changes in dopamine release. Microinjection of 2-chloroadenosine depressed both the ascorbate and the HVA signals; the infusion of adenosine deaminase increased the amplitude of the two signals. These results, considered in the light of lesion + binding studies, suggest that released endogenous adenosine may modulate the release of transmitter from both corticostriatal and nigrostriatal terminals. The effect of adenosine deaminase on the urate signal provides preliminary evidence that changes in this signal may reflect variations in the release of adenosine.
影响因子：
13.9
作者：
S. Snyder
通讯作者：
S. Snyder
腺苷受体：放射自显影证据表明它们位于兴奋性神经元的轴突末端。
DOI：
10.1126/science.6302841
发表时间：
1983
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Goodman,RR;Kuhar,MJ;Hester,L;Snyder,SH
通讯作者：
Snyder,SH