ANX7 as a bio-marker in prostate and breast cancer progression.
ANX7 as a bio-marker in prostate and breast cancer progression.
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DOI:
10.1155/2001/239602
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发表时间:
2001
期刊:
影响因子:
--
通讯作者:
Pollard HB
中科院分区:
文献类型:
--
作者:
Srivastava M;Bubendorf L;Nolan L;Glasman M;Leighton X;Miller G;Fehrle W;Raffeld M;Eidelman O;Kallioniemi OP;Srivastava S;Pollard HB
The ANX7 gene codes for a Ca2+-activated GTPase, which has been implicated in both exocytotic secretion in cells and control of growth. In this review, we summarize information regarding increased tumor frequency in the Anx7 knockout mice, ANX7 growth suppression of human cancer cell lines, and ANX7 expression in human tumor tissue micro-arrays. The loss of ANX7 is significant in metastatic and hormone refractory prostate cancer compared to benign prostatic hyperplasia. In addition, ANX7 expression has prognostic value for predicting survival of breast cancer patients.
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影响因子:
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