ANX7 as a bio-marker in prostate and breast cancer progression.

ANX7 as a bio-marker in prostate and breast cancer progression.
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DOI:
10.1155/2001/239602
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发表时间:
2001
期刊:
影响因子:
--
通讯作者:
Pollard HB
Pollard HB
中科院分区:
医学4区
文献类型:
--
作者:
Srivastava M;Bubendorf L;Nolan L;Glasman M;Leighton X;Miller G;Fehrle W;Raffeld M;Eidelman O;Kallioniemi OP;Srivastava S;Pollard HB

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ANX7基因编码Ca2+激活的GTPase,这与细胞的胞外分泌和生长控制有关。在这篇综述中,我们总结了有关Anx7基因敲除小鼠肿瘤频率增加、Anx7生长抑制人类癌细胞系以及Anx7在人类肿瘤组织微阵列中的表达的信息。与良性前列腺增生相比,在转移性和激素难治性前列腺癌中,ANX7的缺失是显著的。此外,ANX7的表达对预测乳腺癌患者的生存具有预后价值。
The ANX7 gene codes for a Ca2+-activated GTPase, which has been implicated in both exocytotic secretion in cells and control of growth. In this review, we summarize information regarding increased tumor frequency in the Anx7 knockout mice, ANX7 growth suppression of human cancer cell lines, and ANX7 expression in human tumor tissue micro-arrays. The loss of ANX7 is significant in metastatic and hormone refractory prostate cancer compared to benign prostatic hyperplasia. In addition, ANX7 expression has prognostic value for predicting survival of breast cancer patients.
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