The tumor-to-liver ratio of the standardized uptake value is a useful FDG-PET/CT parameter for predicting malignant intraductal papillary mucinous neoplasm of the pancreas.
The tumor-to-liver ratio of the standardized uptake value is a useful FDG-PET/CT parameter for predicting malignant intraductal papillary mucinous neoplasm of the pancreas.
复制标题
DOI：
10.1002/ags3.12562
复制
发表时间：
2022-09
影响因子：
2.7
通讯作者：
Takada, Yasutsugu
中科院分区：
文献类型：
--
作者：
Utsunomiya, Takeshi;Ogawa, Kohei;Funamizu, Naotake;Sakamoto, Katsunori;Watanabe, Jota;Otani, Hiromi;Kawaguchi, Naoto;Miyagawa, Masao;Iwaki, Hirotaka;Takada, Yasutsugu
本研究旨在探讨18氟脱氧葡萄糖正电子发射断层扫描（FDG-PET/CT）预测恶性导管内乳头状黏液性肿瘤（IPMN）的有效性。回顾性分析了2009年4月至2020年12月在爱媛大学医院和爱媛县中央医院手术后病理诊断为IPMN的88例患者的记录。评估患者的特征、血液化学和影像学检查作为恶性IPMN的潜在预测因素。在PET/CT结果中，比较了肿瘤的最大标准化摄取值（SUVmax）、SUV的肿瘤-血池比（TBR）和SUV的肿瘤-肝脏比（TLR）。在病理学上，40例患者诊断为腺瘤（IPMA），26例患者诊断为高度异型增生（HGD），22例患者诊断为癌（IPMC）。HGD和IPMC定义为恶性IPMN。在多变量分析中，TLR ≥ 1.3和高风险柱头是恶性IPMN的独立预测因子（分别为P = .001和P = .007）。当HRS和TLR均≥ 1.3时，恶性肿瘤的阳性预测值为88.2%。此外，IPMC患者的TLR显著高于HGD患者（P = 0.039）。TLR可以作为区分良性与恶性IPMN的有用预测因素，并且可能与术后结局相关。虽然肿瘤的FDG PET/CT最大标准化摄取值（SUVmax）是一个有用的参数，但它不是一个绝对值，而是一个相对值，受设备和成像方案等多种因素的影响。为了使SUVmax更普遍，研究了肿瘤的SUVmax与肝右叶（TLR）的SUV平均值的比率。目前的研究表明，TLR可以是一个有用的预测区分良性和恶性IPMN，并可能与结果，如术后复发。
The present study aimed to investigate the efficacy of positron emission tomography with 18Fluoro‐deoxyglucose (FDG‐PET/CT) for predicting malignant intraductal papillary mucinous neoplasm (IPMN). The records of 88 patients pathologically diagnosed with IPMN after surgery at Ehime University Hospital and Ehime Prefectural Central Hospital from April 2009 to December 2020 were retrospectively reviewed. The patients’ characteristics, blood chemistry, and imaging examinations were evaluated as potential predictors of malignant IPMN. Of the PET/CT results, the maximum standardized uptake value (SUVmax) of the tumor, the tumor‐to‐blood pool ratio of the SUV (TBR), and the tumor‐to‐liver ratio of the SUV (TLR) were compared. On pathology, the diagnosis was adenoma (IPMA) in 40 patients, high‐grade dysplasia (HGD) in 26 patients, and carcinoma (IPMC) in 22 patients. HGD and IPMC were defined as malignant IPMN. On multivariate analyses, TLR ≥ 1.3 and high‐risk stigmata were independent predictors of malignant IPMN (P = .001 and P = .007, respectively). When both HRS and TLR ≥ 1.3 were present, the positive predictive value for malignancy was 88.2%. Furthermore, TLR was significantly higher for patients with IPMC than with HGD (P = .039). TLR can be a useful predictor for differentiating benign from malignant IPMN and may be associated with postoperative outcomes. Although the FDG PET/CT maximum standardized uptake value (SUVmax) of the tumor is a useful parameter, it is not an absolute value but a relative value, and it is affected by various factors such as equipment and imaging protocols. In order to make SUVmax more universal, the ratio of SUVmax of the tumor to SUV mean of the liver right lobe (TLR) was investigated. The present study showed that the TLR can be a useful predictor for differentiating benign from malignant IPMNs and may be associated with outcomes, such as postoperative recurrence.
登录
查看更多内容
C反应蛋白/白蛋白比预测晚期胰腺癌患者的总生存率。
影响因子：
--
作者：
Wu, Mengwan;Guo, Jing;Guo, Lihong;Zuo, Qiang
通讯作者：
Zuo, Qiang
影响因子：
9
作者：
Fong, Zhi Ven;Correa-Gallego, Camilo;Fernandez-del Castillo, Carlos
通讯作者：
Fernandez-del Castillo, Carlos
影响因子：
9.3
作者：
Na, Sae Jung;Oh, Jin Kyoung;Yun, Mijin
通讯作者：
Yun, Mijin
影响因子：
10.6
作者：
Jolepalem, Prashant;Rydberg, John N.;Wong, C. Y. Oliver
通讯作者：
Wong, C. Y. Oliver
影响因子：
3.6
作者：
Ohta, Koji;Tanada, Minoru;Iguchi, Haruo
通讯作者：
Iguchi, Haruo