The C-reactive protein/albumin ratio predicts overall survival of patients with advanced pancreatic cancer.
The C-reactive protein/albumin ratio predicts overall survival of patients with advanced pancreatic cancer.
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C反应蛋白/白蛋白比预测晚期胰腺癌患者的总生存率。
DOI：
10.1007/s13277-016-5122-y
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Zuo, Qiang
中科院分区：
文献类型：
--
作者：
Wu, Mengwan;Guo, Jing;Guo, Lihong;Zuo, Qiang
最近的研究已经证明了C-反应蛋白/白蛋白（CRP/Alb）比值在癌症中的预后价值。然而，CRP/Alb比值在晚期胰腺癌（PC）中的作用尚未研究。对233例晚期PC患者进行了回顾性研究。我们研究了CRP/Alb比值、临床病理变量和总生存期（OS）之间的关系。CRP/Alb比值的最佳临界点为0.54。CRP/Alb比值升高与嗜中性淋巴细胞比率（NLR）升高（P < 0.001）和改良格拉斯哥预后评分（mGPS）升高（P < 0.001）显著相关。使用单变量分析，我们发现，（P = 0.009），疾病分期（P < 0.001），NLR（P < 0.001），mGPS CRP/Alb比值（P < 0.001）CRP/Alb比值高的患者OS较CRP/Alb比值低的患者差（风险比（HR）3.619; 95%CI 2.681-4.886; P < 0.001）。而CRP/Alb比值在多因素分析中被认为是唯一具有独立预后能力的炎症相关指标（P < 0.001）。治疗前CRP/Alb比值是晚期PC患者OS的上级预后和治疗预测因子。
Recent studies have demonstrated the prognostic value of the C-reactive protein/albumin (CRP/Alb) ratio in cancer. However, the role of the CRP/Alb ratio in advanced pancreatic cancer (PC) has not been examined. A retrospective study of 233 patients with advanced PC was conducted. We investigated the relationship between the CRP/Alb ratio, clinicopathological variables, and overall survival (OS). The optimal cutoff point of the CRP/Alb ratio was 0.54. A higher CRP/Alb ratio was significantly associated with an elevated neutrophil-lymphocyte ratio (NLR) (P < 0.001) and higher modified Glasgow prognostic score (mGPS) (P < 0.001). Using univariate analyses, we found that the age (P = 0.009), disease stage (P < 0.001), NLR (P < 0.001), mGPS (P < 0.001), and CRP/Alb ratio (P < 0.001) were significant predictors of OS. Patients with a higher CRP/Alb ratio had a worse OS than patients with a lower CRP/Alb ratio (hazard ratio (HR) 3.619; 95 % CI 2.681–4.886; P < 0.001). However, the CRP/Alb ratio was identified as the only inflammation-based parameter with an independent prognostic ability in the multivariate analyses (P < 0.001). The pretreatment CRP/Alb ratio is a superior prognostic and therapeutic predictor of OS in advanced PC.
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