Wound Healing in the Oral Mucosa

Wound Healing in the Oral Mucosa
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口腔粘膜伤口愈合

DOI:
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发表时间:
2018
期刊:
影响因子:
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通讯作者:
Constanza E. Martínez
Constanza E. Martínez
中科院分区:
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文献类型:
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作者:
Patricio C. Smith;Constanza E. Martínez

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粘膜组织中的伤口愈合在许多方面不同于皮肤伤口愈合,独特的方面是缺乏瘢痕形成。口腔粘膜伤口愈合包括一系列连续的反应,允许该组织中的破裂闭合。这一过程对于防止微生物或其他物质侵入组织,避免慢性炎症的建立至关重要。由于口腔粘膜不断暴露于创伤和感染的挑战,该组织已经发展出进化策略来规避这种不利的环境。因此,口腔粘膜在伤口愈合反应的效率方面具有几个优点。伤口愈合也可能在慢性炎性疾病和癌症发展过程中发生的细胞和组织反应中发挥重要作用。因此,了解调节伤口愈合的机制对于理解该组织中的病理事件至关重要。
Wound healing in mucosal tissues differs in many aspects from cutaneous wound healing, a unique aspect being the lack of scar formation. Oral mucosa wound healing comprises a series of sequential responses that allow the closure of ruptures in this tissue. This process is of critical importance to prevent the invasion of microorganisms or other agents into tissues avoiding the establishment of chronic inflammation. Since the oral mucosa is continually exposed to traumatic and infectious challenges, this tissue has developed evolutionary strategies to circumvent this adverse environment. Therefore, the oral mucosa has several advantages in terms of the efficiency of the wound healing response. Wound healing may also play an important role during the cell and tissue reactions that occur during the development of chronic inflammatory diseases and cancer. Therefore, knowledge of the mechanisms that regulate wound healing is essential for the comprehension of pathological events in this tissue.
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