Therapeutic Potential of Glycosyl Flavonoids as Anti-Coronaviral Agents.
Therapeutic Potential of Glycosyl Flavonoids as Anti-Coronaviral Agents.
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DOI：
10.3390/ph14060546
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发表时间：
2021-06-07
期刊：
影响因子：
--
通讯作者：
Silva VLM
中科院分区：
文献类型：
--
作者：
Godinho PIC;Soengas RG;Silva VLM
由严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）引起的COVID-19大流行已蔓延至世界各地，造成了毁灭性的社会经济影响。尽管保护性疫苗已经开始接种，但预防和治疗COVID-19的有效抗病毒药物尚未问世。此外，由于新的和致命的冠状病毒随时可能出现，并有可能成为大流行病，因此开发针对潜在致命冠状病毒的治疗剂是当前非常感兴趣的研究领域。在寻找抗冠状病毒药物的过程中，研究人员很快就把注意力转向了糖基化的类黄酮。糖基黄酮类化合物广泛存在于植物界，因其具有抗氧化、抗炎、神经保护、抗癌、抗糖尿病、抗菌和抗病毒等特性以及调节关键细胞功能的能力而受到广泛关注。糖基类黄酮具有广泛的生物活性和较低的毒性，是药物开发的理想候选物质。在这篇综述中，我们回顾并讨论了糖基黄酮类化合物作为冠状病毒抗病毒药物的循证天然来源的最新进展及其在COVID-19管理中的潜在作用。
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread all over the world, creating a devastating socio-economic impact. Even though protective vaccines are starting to be administered, an effective antiviral agent for the prevention and treatment of COVID-19 is not available yet. Moreover, since new and deadly CoVs can emerge at any time with the potential of becoming pandemics, the development of therapeutic agents against potentially deadly CoVs is a research area of much current interest. In the search for anti-coronaviral drugs, researchers soon turned their heads towards glycosylated flavonoids. Glycosyl flavonoids, widespread in the plant kingdom, have received a lot of attention due to their widely recognized antioxidant, anti-inflammatory, neuroprotective, anticarcinogenic, antidiabetic, antimicrobial, and antiviral properties together with their capacity to modulate key cellular functions. The wide range of biological activities displayed by glycosyl flavonoids, along with their low toxicity, make them ideal candidates for drug development. In this review, we examine and discuss the up-to-date developments on glycosyl flavonoids as evidence-based natural sources of antivirals against coronaviruses and their potential role in the management of COVID-19.
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DOI：
10.3390/antiox9100936
发表时间：
2020-09-29
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
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7.6
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影响因子：
5
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