The efficiency of the human CD8+ T cell response: how should we quantify it, what determines it, and does it matter?

The efficiency of the human CD8+ T cell response: how should we quantify it, what determines it, and does it matter?
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人CD8+ T细胞响应的效率:我们应该如何量化它,什么决定它,这有关系?

DOI:
10.1371/journal.pcbi.1002381
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发表时间:
2012
影响因子:
4.3
通讯作者:
Asquith B
Asquith B
中科院分区:
生物学2区
文献类型:
--
作者:
Elemans M;Seich Al Basatena NK;Asquith B

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多学科技术,特别是理论和实验免疫学的结合,可以解决用其他方法无法回答的关于人类免疫的问题。从体内病毒感染细胞的周转率到胸腺生成率和HLA I类表位预测,理论技术为补充实验方法提供了独特的见解。在这里,我们提出我们的观点,并举例说明数学在我们感兴趣的领域中做出贡献的一些方式:人类CD8+ T细胞对持久性病毒的反应效率。
Multidisciplinary techniques, in particular the combination of theoretical and experimental immunology, can address questions about human immunity that cannot be answered by other means. From the turnover of virus-infected cells in vivo, to rates of thymic production and HLA class I epitope prediction, theoretical techniques provide a unique insight to supplement experimental approaches. Here we present our opinion, with examples, of some of the ways in which mathematics has contributed in our field of interest: the efficiency of the human CD8+ T cell response to persistent viruses.
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