Validation of the Oxford classification of IgA nephropathy: a single-center study in Korean adults.
Validation of the Oxford classification of IgA nephropathy: a single-center study in Korean adults.
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DOI：
10.3904/kjim.2012.27.3.293
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Kwon SH
中科院分区：
文献类型：
--
作者：
Lee H;Yi SH;Seo MS;Hyun JN;Jeon JS;Noh H;Han DC;Hwang SD;Jin SY;Kwon SH
最近发表的伊加肾病牛津分类（IgAN）提出了一个分裂系统的组织学分级，预后病理特征的基础上。这一新的分类系统必须在各种群组中得到验证。我们调查了这些病理特征是否适用于韩国成年人群。韩国首尔顺天乡大学医院使用牛津分类系统总共分析了69名韩国成年IgAN患者。所有病例均按Lee分类法进行分类。来自所有患者的肾活检由对病理变量的临床数据不知情的病理学家进行评分。入选标准为年龄大于18岁和至少随访36个月。我们排除了继发性IgAN、糖尿病肾病合并其他肾小球疾病、随访时间少于36个月以及进展迅速的病例。患者的中位年龄为34岁（范围：27 - 45岁）。活检时平均动脉血压为97 ± 10 mmHg。中位随访期为85个月（范围：60 - 114）。Kaplan-Meier分析显示M、E和T病变的显著预后预测。考克斯比例风险回归分析也揭示了E和T病变的预后预测。在考虑临床变量后，使用IgAN、E和T病变的牛津分类预测韩国成人的肾脏结局。
The recently published Oxford classification of IgA nephropathy (IgAN) proposed a split system for histological grading, based on prognostic pathological features. This new classification system must be validated in a variety of cohorts. We investigated whether these pathological features were applicable to an adult Korean population. In total, 69 adult Korean patients with IgAN were analyzed using the Oxford classification system at Soonchunhyang University Hospital, Seoul, Korea. All cases were categorized according to Lee's classification. Renal biopsies from all patients were scored by a pathologist who was blinded to the clinical data for pathological variables. Inclusion criteria were age greater than 18 years and at least 36 months of follow-up. We excluded cases with secondary IgAN, diabetic nephropathy combined other glomerulopathies, less than 36 months of follow-up, and those that progressed rapidly. The median age of the patients was 34 years (range, 27 to 45). Mean arterial blood pressure was 97 ± 10 mmHg at the time of biopsy. The median follow-up period was 85 months (range, 60 to 114). Kaplan-Meier analysis showed significant prognostic predictions for M, E, and T lesions. A Cox proportional hazard regression analysis also revealed prognostic predictions for E and T lesions. Using the Oxford classification in IgAN, E, and T lesions predicted renal outcome in Korean adults after taking clinical variables into account.
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