CSF cytokine profile in MOG-IgG+ neurological disease is similar to AQP4-IgG+ NMOSD but distinct from MS: a cross-sectional study and potential therapeutic implications.
CSF cytokine profile in MOG-IgG+ neurological disease is similar to AQP4-IgG+ NMOSD but distinct from MS: a cross-sectional study and potential therapeutic implications.
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DOI：
10.1136/jnnp-2018-317969
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Aoki M
中科院分区：
文献类型：
--
作者：
Kaneko K;Sato DK;Nakashima I;Ogawa R;Akaishi T;Takai Y;Nishiyama S;Takahashi T;Misu T;Kuroda H;Tanaka S;Nomura K;Hashimoto Y;Callegaro D;Steinman L;Fujihara K;Aoki M
评估成人和儿童髓鞘少突胶质细胞糖蛋白igg阳性（MOG-IgG+）疾病患者脑脊液（CSF）细胞因子谱。在这项横断面研究中，我们测量了治疗前急性期MOG-IgG+疾病CSF中的27种细胞因子（n=29）。直接与水通道蛋白-4抗体阳性（AQP4-IgG+）视神经脊髓炎谱系障碍（NMOSD） （n=20）、多发性硬化症（MS） （n=20）和非炎症对照组（n=14）的数据进行比较。与AQP4-IgG+ NMOSD（41,15 - 77）和MS（34,17 - 48）相比，MOG-IgG+疾病无女性优势，年龄更年轻（平均18岁，3-68岁，18岁以下15岁）。与ms相比，MOG-IgG+疾病和AQP4-IgG+ NMOSD患者脑脊液细胞计数较高，寡克隆IgG带多为阴性。MOG-IgG+疾病患者白细胞介素(IL)-6、IL-8、粒细胞集落刺激因子、粒细胞巨噬集落刺激因子、干扰素-γ、IL-10、IL-1受体拮抗剂水平显著升高。单核细胞趋化蛋白-1和巨噬细胞炎症蛋白-1α与ms比较，MOG-IgG+疾病的细胞因子与AQP4-IgG+ NMOSD无显著差异。此外，许多升高的细胞因子在MOG-IgG+疾病和AQP4-IgG+ NMOSD中相互关联，而在ms中则无相关性。在MOG-IgG+疾病急性期，CSF细胞因子谱的特征是T辅助17 （Th17）和其他细胞因子（包括一些th1相关和调节性T细胞相关细胞因子）在成人和儿童中协同上调，这与AQP4-IgG+ NMOSD相似，但与MS明显不同。结果表明，与AQP4-IgG+ NMOSD一样，MS的一些疾病改善药物在MOG-IgG+疾病中可能无效，但可能提供潜在的治疗靶点。
To evaluate cerebrospinal fluid (CSF) cytokine profiles in myelin oligodendrocyte glycoprotein IgG-positive (MOG-IgG+) disease in adult and paediatric patients. In this cross-sectional study, we measured 27 cytokines in the CSF of MOG-IgG+ disease in acute phase before treatment (n=29). The data were directly compared with those in aquaporin-4 antibody-positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD) (n=20), multiple sclerosis (MS) (n=20) and non-inflammatory controls (n=14). In MOG-IgG+ disease, there was no female preponderance and the ages were younger (mean 18 years, range 3–68; 15 were below 18 years) relative to AQP4-IgG+ NMOSD (41, 15–77) and MS (34, 17–48). CSF cell counts were higher and oligoclonal IgG bands were mostly negative in MOG-IgG+ disease and AQP4-IgG+ NMOSD compared with MS. MOG-IgG+ disease had significantly elevated levels of interleukin (IL)-6, IL-8, granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor, interferon-γ, IL-10, IL-1 receptor antagonist, monocyte chemotactic protein-1 and macrophage inflammatory protein-1α as compared with MS. No cytokine in MOG-IgG+ disease was significantly different from AQP4-IgG+ NMOSD. Moreover many elevated cytokines were correlated with each other in MOG-IgG+ disease and AQP4-IgG+ NMOSD but not in MS. No difference in the data was seen between adult and paediatric MOG-IgG+ cases. The CSF cytokine profile in the acute phase of MOG-IgG+ disease is characterised by coordinated upregulation of T helper 17 (Th17) and other cytokines including some Th1-related and regulatory T cells-related ones in adults and children, which is similar to AQP4-IgG+ NMOSD but clearly different from MS. The results suggest that as with AQP4-IgG+ NMOSD, some disease-modifying drugs for MS may be ineffective in MOG-IgG+ disease while they may provide potential therapeutic targets.
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影响因子：
5.8
作者：
Min, Ju-Hong;Kim, Byoung Joon;Lee, Kwang Ho
通讯作者：
Lee, Kwang Ho
MOG 抗体具有脱髓鞘表型并影响少突胶质细胞骨架。
DOI：
10.1212/nxi.0000000000000012
发表时间：
2014-06
期刊：
Neurology(R) neuroimmunology & neuroinflammation
影响因子：
--
作者：
Dale RC;Tantsis EM;Merheb V;Kumaran RY;Sinmaz N;Pathmanandavel K;Ramanathan S;Booth DR;Wienholt LA;Prelog K;Clark DR;Guillemin GJ;Lim CK;Mathey EK;Brilot F
通讯作者：
Brilot F
DOI：
10.1212/nxi.0000000000000175
发表时间：
2015-12-01
影响因子：
8.8
作者：
Di Pauli, Franziska;Hoftberger, Romana;Berger, Thomas
通讯作者：
Berger, Thomas
影响因子：
9.3
作者：
Berg CT;Khorooshi R;Asgari N;Owens T
通讯作者：
Owens T
影响因子：
3.3
作者：
Horellou, Philippe;Wang, Min;Deiva, Kumaran
通讯作者：
Deiva, Kumaran