Phase-contrast MRI-based elastography technique detects early hypertensive changes in ex vivo porcine aortic wall.
Phase-contrast MRI-based elastography technique detects early hypertensive changes in ex vivo porcine aortic wall.
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DOI：
10.1002/jmri.21702
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发表时间：
2009-03
影响因子：
4.4
通讯作者：
Ehman, Richard L.
中科院分区：
文献类型：
--
作者：
Woodrum, David A.;Herrmann, Joerg;Lerman, Amir;Romano, Anthony J.;Lerman, Lilach O.;Ehman, Richard L.
关键词：
使用基于相位对比MRI的弹性成像技术测量对照组和高血压组离体猪髂动脉的弹性特性。将雌性家猪随机分为正常对照组（N; n=5）或肾血管性高血压组（HT; n=5），持续3个月。高血压组的平均动脉压显著高于对照组（173 ± 12 vs. 115 ± 11 mmHg，p≤0.05）。在高血压3个月后对动物实施安乐死，并收获腹部赘肉。然后使用基于相位对比MRI的弹性成像技术检查离体主动脉样本。反映血管硬度的杨氏模量-壁厚乘积在高血压组显著高于对照组（0.571 ± 0.080 vs.0.419 ± 0.026，p<0.05）。组织学分析和染色证实高血压主动脉内膜中层厚度和胶原含量增加，而弹性蛋白染色显示无差异。目前的研究表明，磁共振弹性成像提供了一种方法来研究动脉壁的生理变化继发于早期高血压。
To measure the elastic properties of ex-vivo porcine aortas in control and hypertensive groups using a phase contrast MRI-based elastography technique. Female domestic pigs were randomized to a normal control group (N; n=5) or a renovascular hypertension group (HT; n=5) for the duration of 3 months. Mean arterial pressure was significantly higher in the hypertension group than in the control group (173 ± 12 vs. 115 ± 11 mmHg, p≤0.05). The animals were euthanized after 3 months of hypertension and abdominal aortas harvested. The ex-vivo aortic samples were then examined using a phase contrast MRI-based elastography technique. The Young's modulus-wall thickness product, a reflection of vascular stiffness, was significantly higher in the hypertension group than in the control group (0.571 ± 0.080 vs. 0.419 ± 0.026, p<0.05). Histological analysis and staining confirmed increased intima-media thickness and collagen content in the hypertensive aorta, while elastin staining showed no difference. The current study shows that MR elastography offers a method to study the physiologic changes in the arterial wall secondary to early hypertension.
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影响因子：
56.9
作者：
MUTHUPILLAI, R;LOMAS, DJ;EHMAN, RL
通讯作者：
EHMAN, RL
影响因子：
3.3
作者：
Draney, MT;Arko, FR;Taylor, CA
通讯作者：
Taylor, CA
影响因子：
3.2
作者：
Nichols, WW
通讯作者：
Nichols, WW
DOI：
10.1161/01.atv.0000077477.40824.52
发表时间：
2003-07-01
影响因子：
8.7
作者：
Chade, AR;Rodriguez-Porcel, M;Lerman, LO
通讯作者：
Lerman, LO
影响因子：
3.3
作者：
Romano, AJ;Abraham, PB;Ehman, RL
通讯作者：
Ehman, RL