rs4919510 in hsa-mir-608 is associated with outcome but not risk of colorectal cancer.
rs4919510 in hsa-mir-608 is associated with outcome but not risk of colorectal cancer.
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DOI：
10.1371/journal.pone.0036306
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Harris CC
中科院分区：
文献类型：
--
作者：
Ryan BM;McClary AC;Valeri N;Robinson D;Paone A;Bowman ED;Robles AI;Croce C;Harris CC
结直肠癌是美国第三大癌症发病率和癌症相关死亡原因。 MicroRNA是一类小非编码RNA，与结直肠癌的发病机制和预后有关，尽管很少有研究探讨microRNA种系突变与风险和预后之间的关系。因此，我们研究了位于 10q24 位点内的 hsa-mir-608 中的 SNP 与结直肠癌之间的关联。对由 245 名病例和 446 名对照组成的队列进行了 rs4919510 基因分型。与白人对照 (3%) 相比，非洲裔美国人 (15%) 的 GG 基因型频率显着更高。 rs4919510 与结直肠癌风险之间没有显着关联（非洲裔美国人：ORGG 与 CC 0.89 [95% CI，0.41–1.80]）（白种人：ORGG 与 CC 1.76，（[95% CI，0.48–6.39]）。然而，我们确实观察到与生存的关联。GG 基因型与死亡风险增加相关。白种人（HRGG 与 CC 3.54（[95% CI，1.38–9.12]）和非洲裔美国人（HRGG 与 CC 0.36（[95% CI 0.12–1.07））死亡风险降低。这些结果表明 rs4910510 可能与结直肠癌生存相关，其方式取决于种族。
Colorectal cancer is the third most incident cancer and cause of cancer-related death in the United States. MicroRNAs, a class of small non-coding RNAs, have been implicated in the pathogenesis and prognosis of colorectal cancer, although few studies have examined the relationship between germline mutation in the microRNAs with risk and prognosis. We therefore investigated the association between a SNP in hsa-mir-608, which lies within the 10q24 locus, and colorectal cancer. A cohort consisting of 245 cases and 446 controls was genotyped for rs4919510. The frequency of the GG genotype was significantly higher in African Americans (15%) compared to Caucasians (3%) controls. There was no significant association between rs4919510 and colorectal cancer risk (African American: ORGG vs. CC 0.89 [95% CI, 0.41–1.80]) (Caucasian: ORGG vs. CC 1.76, ([95% CI, 0.48–6.39]). However, we did observe an association with survival. The GG genotype was associated with an increased risk of death in Caucasians (HRGG vs. CC 3.54 ([95% CI, 1.38–9.12]) and with a reduced risk of death in African Americans (HRGG vs. CC 0.36 ([95% CI 0.12–1.07). These results suggest that rs4910510 may be associated with colorectal cancer survival in a manner that is dependent on race.
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DOI：
10.1073/pnas.0802682105
发表时间：
2008-05-20
影响因子：
11.1
作者：
Jazdzewski, Krystian;Murray, Elizabeth L.;de la Chapelle, Albert
通讯作者：
de la Chapelle, Albert
影响因子：
120.7
作者：
Schetter, Aaron J.;Leung, Suet Yi;Harris, Curtis C.
通讯作者：
Harris, Curtis C.
影响因子：
9.8
作者：
Quach, Helene;Barreiro, Luis B.;Quintana-Murci, Lluis
通讯作者：
Quintana-Murci, Lluis
影响因子：
14.9
作者：
Griffiths-Jones S;Grocock RJ;van Dongen S;Bateman A;Enright AJ
通讯作者：
Enright AJ
影响因子：
7
作者：
Thorisson, GA;Smith, AV;Stein, LD
通讯作者：
Stein, LD