The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad.
The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad.
复制标题
在怀孕期间接种SARS-CoV-2疫苗的好处有利于母亲/新生儿二联体。
DOI：
10.3390/vaccines10060848
复制
发表时间：
2022-05-26
期刊：
影响因子：
7.8
通讯作者：
Boia, Marioara
中科院分区：
文献类型：
--
作者：
Popescu, Daniela-Eugenia;Citu, Cosmin;Jura, Ana Maria Cristina;Lungu, Nicoleta;Navolan, Dan;Craina, Marius;Semenescu, Alin;Gorun, Florin;Jura, Mihai-Andrei;Belengeanu, Valerica;Boia, Marioara
当针对SARS-CoV-2的第一批疫苗出现时，孕妇被排除在临床试验之外，因此疫苗建议最初被推迟，这一人群类别的启动时间较晚。本研究的目的是量化的血清和母乳值的SARS-CoV-2刺突蛋白抗体在母亲和她的新生儿在怀孕期间完成疫苗接种后。研究纳入了91名接种疫苗的患者，其中一些患者在怀孕期间出现COVID-19感染。在产房，从母亲身上采集静脉血，从她的后代身上采集脐带血。使用ECLIA（电化学发光）方法处理所有样品。在产后第三天收集母乳并进行检测。最高母体血清值为19，523 U/mL（检测限> 0.8 U/mL），母乳中为206.7 U/mL。每一个新生儿的抗体值均大于0，平均血清值（M = 5288.37，SD = 5661.49）显著高于0，t（90）= 8.91，p < 0.001。因此，本研究旨在强调在怀孕期间接种SARS-CoV-2疫苗的重要性。这种通过胎盘和母乳转移实现的新生儿双重保护，可以通过鼓励接种疫苗、母乳喂养、建立联系和赋予母亲参与婴儿护理的权能来实现。
When the first vaccines against SARS-CoV-2 emerged, pregnant women were excluded from clinical trials, so vaccine recommendations were initially adjourned, with late initiation for this populational category. The present study aims to quantify the serum and breastmilk values of SARS-CoV-2 spike protein antibodies in both the mother and her newborn after complete vaccination during pregnancy. Ninety-one vaccinated patients were included, some of whom presented COVID-19 infection during pregnancy. In the delivery room, venous blood was collected from the mother and umbilical cord blood from her offspring. All samples were processed using the ECLIA (electrochemiluminescence) method. Breastmilk was collected and tested during the third postnatal day. The highest maternal serum values were 19,523 U/mL (detection limit > 0.8 U/mL) and in breastmilk, 206.7 U/mL. Every single newborn had antibody values higher than 0, with a mean serum value (M = 5288.37, SD = 5661.49) significantly higher than 0, t(90) = 8.91, p < 0.001. Consequently, this study intents to emphasize the importance of vaccination against SARS-CoV-2 during pregnancy. This double kind of neonatal protection, attained by placental and breastmilk transfer, can be accomplished by encouraging vaccination, breastfeeding, bonding, and providing maternal empowerment to participate in her infant’s care.
登录
查看更多内容
影响因子：
13.6
作者：
Skjefte M;Ngirbabul M;Akeju O;Escudero D;Hernandez-Diaz S;Wyszynski DF;Wu JW
通讯作者：
Wu JW
DOI：
10.15585/mmwr.mm6944e3
发表时间：
2020-11-06
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Zambrano LD;Ellington S;Strid P;Galang RR;Oduyebo T;Tong VT;Woodworth KR;Nahabedian JF 3rd;Azziz-Baumgartner E;Gilboa SM;Meaney-Delman D;CDC COVID-19 Response Pregnancy and Infant Linked Outcomes Team
通讯作者：
CDC COVID-19 Response Pregnancy and Infant Linked Outcomes Team
DOI：
10.3390/v14020307
发表时间：
2022-02-02
期刊：
Viruses
影响因子：
--
作者：
Citu IM;Citu C;Gorun F;Sas I;Tomescu L;Neamtu R;Motoc A;Gorun OM;Burlea B;Bratosin F;Malita D
通讯作者：
Malita D
影响因子：
7.2
作者：
Rasmussen, Sonja A.;Kelley, Colleen F.;Jamieson, Denise J.
通讯作者：
Jamieson, Denise J.
怀孕期间和早产儿或小于胎龄儿期间接受 COVID-19 疫苗 - 美国八个综合医疗保健组织，2020 年 12 月 15 日至 2021 年 7 月 22 日。
DOI：
10.15585/mmwr.mm7101e1
发表时间：
2022-01-07
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Lipkind HS;Vazquez-Benitez G;DeSilva M;Vesco KK;Ackerman-Banks C;Zhu J;Boyce TG;Daley MF;Fuller CC;Getahun D;Irving SA;Jackson LA;Williams JTB;Zerbo O;McNeil MM;Olson CK;Weintraub E;Kharbanda EO
通讯作者：
Kharbanda EO