The construction of a Chinese MRI brain atlas: a morphometric comparison study between Chinese and Caucasian cohorts.
The construction of a Chinese MRI brain atlas: a morphometric comparison study between Chinese and Caucasian cohorts.
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DOI：
10.1016/j.neuroimage.2010.01.111
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发表时间：
2010-05-15
期刊：
影响因子：
5.7
通讯作者：
Toga, Arthur W.
中科院分区：
文献类型：
--
作者：
Tang, Yuchun;Hojatkashani, Cornelius;Dinov, Ivo D.;Sun, Bo;Fan, Lingzhong;Lin, Xiangtao;Qi, Hengtao;Hua, Xue;Liu, Shuwei;Toga, Arthur W.
我们开发了一个新的脑图谱模板，以促进使用高质量磁共振成像（MRI）和经过验证的图像分析技术对中国受试者和人群进行计算脑研究。为了探讨基于种族的脑结构差异，我们对35名中国男性受试者（24.03±2.06岁）进行了MRI扫描，并将其与年龄匹配的35名高加索男性受试者（24.03±2.06岁）进行了比较。使用整体体积测量来确定脑长度、宽度、高度和交流- pc线距离的显著组差异。使用LONI BrainParser，对所有受试者的56个大脑结构进行了自动标记和分析。我们发现了脑结构体积的显著种族差异，这表明针对人群的脑图谱可能更适合于中国人群的研究。为了解决这个问题，我们基于高分辨率3.0T MRI扫描56名右撇子男性志愿者（24.46±1.81岁）构建了三维中国人脑图谱。在LONI管道环境下，通过“AIR Make Atlas”管道工作流对所有中国人的大脑进行线性和非线性的空间归一化处理。这个高分辨率的中国脑图谱与使用高加索人大脑构建的ICBM152模板进行了比较。
We developed a novel brain atlas template to facilitate computational brain studies of Chinese subjects and populations using high quality magnetic resonance imaging (MRI) and well-validated image analysis techniques. To explore the ethnicity-based structural brain differences, we used the MRI scans of 35 Chinese male subjects (24.03±2.06yr) and compared them to an age-matched cohort of 35 Caucasian males (24.03±2.06yr). Global volumetric measures were used to identify significant group differences in the brain length, width, height and AC-PC line distance. Using the LONI BrainParser, 56 brain structures were automatically labeled and analyzed for all subjects. We identified significant ethnicity differences in brain structure volumes, suggesting that a population-specific brain atlas may be more appropriate for studies involving Chinese populations. To address this, we constructed a 3D Chinese brain atlas based on high resolution 3.0T MRI scans of 56 right-handed male Chinese volunteers (24.46±1.81yr). All Chinese brains were spatially normalized by using linear and nonlinear transformation via the “AIR Make Atlas” pipeline workflow within the LONI pipeline environment. This high-resolution Chinese brain atlas was compared to the ICBM152 template, which was constructed using Caucasian brains.
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5.7
作者：
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通讯作者：
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通讯作者：
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