Comparative genomic hybridization and chromosomal instability in solid tumours.

Comparative genomic hybridization and chromosomal instability in solid tumours.
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DOI:
10.1038/sj.bjc.6690433
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发表时间:
1999-05
影响因子:
8.8
通讯作者:
McLeod, HL
McLeod, HL
中科院分区:
医学1区
文献类型:
--
作者:
Rooney, PH;Murray, GI;Stevenson, DAJ;Haites, NE;Cassidy, J;McLeod, HL

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British Journal of Cancer(1999)80(5/6),862-873© Cancer Research Campaign 1999文献。在白血病、淋巴瘤患者中进行的CGH研究或单个染色体结果细节不完整的研究未纳入本综述。由于难以区分初始染色体畸变和细胞培养期间“获得”的染色体畸变,因此未纳入细胞系数据。通过汇集来自所有肿瘤、来自给定肿瘤类型和来自特定肿瘤亚型的数据来确定每个染色体臂的总体丢失或获得的频率。
British Journal of Cancer (1999) 80 (5/6), 862–873© Cancer Research Campaign 1999 literature. Studies of CGH in patients with leukaemia, lymphoma or studies with incomplete details of results for individual chromosomes were not included in this review. Cell line data were not included due to the difficulty in differentiating between initial chromosomal aberrations and those ‘acquired’during cell culture. The frequency of overall loss or gain for each chromosome arm was determined by pooling the data from all tumours, from a given tumour type and from specific tumour subtypes.
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