Plastic modulation of PTSD resting-state networks and subjective wellbeing by EEG neurofeedback.
Plastic modulation of PTSD resting-state networks and subjective wellbeing by EEG neurofeedback.
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DOI：
10.1111/acps.12229
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发表时间：
2014-08
影响因子：
6.7
通讯作者：
Lanius RA
中科院分区：
文献类型：
--
作者：
Kluetsch RC;Ros T;Théberge J;Frewen PA;Calhoun VD;Schmahl C;Jetly R;Lanius RA
脑电图（EEG）神经反馈训练已被证明在健康个体中产生显著性网络和默认模式网络功能连接的可塑性调制。在这项研究中，我们调查了一组PTSD患者中，旨在自愿降低α节律（8-12 Hz）振幅的单次神经反馈训练是否与EEG网络振荡，功能性MRI（fMRI）连接以及状态焦虑和唤醒的主观测量差异有关。21名与儿童虐待有关的PTSD患者接受了30分钟的EEG神经反馈训练，之前和之后进行了静息状态fMRI扫描。α去激活神经反馈与训练过程中α振幅降低相关，随后是静息状态α同步的显著增加（“反弹”）。这种反弹与平静度的增加、与右侧大脑皮层的显著性网络连接的增强以及与双侧后扣带回、右侧额中回和左侧内侧前额叶皮层的默认模式网络连接的增强有关。我们的研究是阐明神经反馈治疗对PTSD调节系统影响的潜在神经行为机制的第一步。此外，它首次记录了神经反馈后自发的EEG“反弹”，指出大脑中的稳态/补偿机制。
Electroencephalographic (EEG) neurofeedback training has been shown to produce plastic modulations in salience network and default mode network functional connectivity in healthy individuals. In this study, we investigated whether a single session of neurofeedback training aimed at the voluntary reduction of alpha rhythm (8–12 Hz) amplitude would be related to differences in EEG network oscillations, functional MRI (fMRI) connectivity, and subjective measures of state anxiety and arousal in a group of individuals with PTSD. 21 individuals with PTSD related to childhood abuse underwent 30 minutes of EEG neurofeedback training preceded and followed by a resting-state fMRI scan. Alpha desynchronizing neurofeedback was associated with decreased alpha amplitude during training, followed by a significant increase (‘rebound’) in resting-state alpha synchronization. This rebound was linked to increased calmness, greater salience network connectivity with the right insula, and enhanced default mode network connectivity with bilateral posterior cingulate, right middle frontal gyrus, and left medial prefrontal cortex. Our study represents a first step in elucidating the potential neurobehavioral mechanisms mediating the effects of neurofeedback treatment on regulatory systems in PTSD. Moreover, it documents for the first time a spontaneous EEG ‘rebound’ after neurofeedback, pointing to homeostatic/compensatory mechanisms operating in the brain.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
影响因子：
3.3
作者：
Drevets, Wayne C.;Savitz, Jonathan
通讯作者：
Savitz, Jonathan
影响因子：
5.7
作者：
Calhoun VD;Liu J;Adali T
通讯作者：
Adali T
DOI：
10.1196/annals.1364.010
发表时间：
2006-01-01
期刊：
PSYCHOBIOLOGY OF POSTTRAUMATIC STRESS DISORDER: A DECADE OF PROGRESS
影响因子：
--
作者：
Frewen, Paul A.;Lanius, Ruth A.
通讯作者：
Lanius, Ruth A.