Robust quantification of orientation selectivity and direction selectivity.
Robust quantification of orientation selectivity and direction selectivity.
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DOI：
10.3389/fncir.2014.00092
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发表时间：
2014
影响因子：
3.5
通讯作者：
Van Hooser SD
中科院分区：
文献类型：
--
作者：
Mazurek M;Kager M;Van Hooser SD
神经元在所有检查哺乳动物的视觉皮层表现出方向或方向调谐。新的成像技术使电路机制的基础上的方向和方向的选择性，以研究清晰，这是不可能的十年前。然而，这些新技术带来了新的挑战：需要强大的定量测量来评估这些研究的结果，这可能涉及数千个不同反应强度的细胞。在这里，我们表明，传统的选择性措施，如取向指数（OI）和方向指数（DI）不适合定量评估的方向和方向调整。我们探讨了几种替代方法，用于量化调谐和解决各种问题，出现在方向和方向调谐的细胞和细胞群的研究。我们提供了哪些方法最适合哪些应用程序的建议，并提供了避免应用这些方法时潜在陷阱的提示。我们的目标是提供一个坚实的定量研究基础，涉及方向和方向调整。
Neurons in the visual cortex of all examined mammals exhibit orientation or direction tuning. New imaging techniques are allowing the circuit mechanisms underlying orientation and direction selectivity to be studied with clarity that was not possible a decade ago. However, these new techniques bring new challenges: robust quantitative measurements are needed to evaluate the findings from these studies, which can involve thousands of cells of varying response strength. Here we show that traditional measures of selectivity such as the orientation index (OI) and direction index (DI) are poorly suited for quantitative evaluation of orientation and direction tuning. We explore several alternative methods for quantifying tuning and for addressing a variety of questions that arise in studies on orientation- and direction-tuned cells and cell populations. We provide recommendations for which methods are best suited to which applications and we offer tips for avoiding potential pitfalls in applying these methods. Our goal is to supply a solid quantitative foundation for studies involving orientation and direction tuning.
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影响因子：
64.8
作者：
Li, Ye;Van Hooser, Stephen D.;Mazurek, Mark;White, Leonard E.;Fitzpatrick, David
通讯作者：
Fitzpatrick, David
影响因子：
2.5
作者：
Moore, BD;Alitto, HJ;Usrey, WM
通讯作者：
Usrey, WM
影响因子：
2.5
作者：
HUMPHREY, AL;NORTON, TT
通讯作者：
NORTON, TT
影响因子：
2.5
作者：
PALMER, LA;DAVIS, TL
通讯作者：
DAVIS, TL
影响因子：
2.9
作者：
ROCHAMIRANDA, CE;LINDEN, R;BOMBARDIERI, RA
通讯作者：
BOMBARDIERI, RA