Phosphorylation of estrogen receptor α at serine 118 is correlated with breast cancer resistance to tamoxifen.
Phosphorylation of estrogen receptor α at serine 118 is correlated with breast cancer resistance to tamoxifen.
复制标题
雌激素受体α丝氨酸118的磷酸化与乳腺癌对他莫昔芬的耐药性相关
DOI：
10.3892/ol.2013.1324
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发表时间：
2013-07
期刊：
影响因子：
2.9
通讯作者：
Zhang GJ
中科院分区：
文献类型：
--
作者：
Chen M;Cui YK;Huang WH;Man K;Zhang GJ
本研究旨在探讨雌激素受体α（ERα）丝氨酸118和167磷酸化与原发性乳腺癌患者对三苯氧胺反应性的关系。对2001年1月至2007年12月在汕头大学医学院附属肿瘤医院接受三苯氧胺辅助治疗的104例原发性乳腺癌患者的肿瘤组织进行了ERα丝氨酸118磷酸化（pERα-S118）和/或丝氨酸167磷酸化（pERα-S167）特异性抗体免疫组化分析。使用Kaplan-Meier生存分析，两个位点的ERα磷酸化与这些患者的无病生存率或总生存率相关。pERα-S118和pERα-S167在乳腺癌细胞核中的表达率分别为25.0%（26/104）和26.9%（28/104）。pERα-S118的表达与HER-2状态呈正相关（χ2=6.85，P=0.01）。Kaplan-Meier分析显示，表达pERα-S118的乳腺癌患者的无病生存期（P=0.022）和总生存期（P=0.013）较低，但表达pERα-S167的患者无病生存期和总生存期较低。总之，pERα-S118与HER-2状态相关，并预测乳腺癌对他莫昔芬的耐药性。
The aim of the present study was to explore the correlation between estrogen receptor α (ERα) phosphorylation at serines 118 and 167 and the responsiveness of patients with primary breast cancer to tamoxifen. Tumors from 104 patients with primary breast cancer who received adjuvant tamoxifen therapy at The Affiliated Cancer Hospital of Shantou University Medical College between January 2001 to December 2007 were subjected to immunohistochemical analysis with specific antibodies against ERα phosphorylated at either serine 118 (pERα-S118) and/or serine 167 (pERα-S167). ERα phosphorylation at the two sites was correlated with either the disease-free survival or the overall survival rate of these patients using the Kaplan-Meier survival analysis. pERα-S118 and pERα-S167 were found to be expressed in the cell nucleus of 25.0% (26/104) and 26.9% (28/104) of breast cancers, respectively. The expression of pERα-S118 was positively correlated with the human epidermal growth factor receptor-2 (HER-2) status (χ2=6.85, P=0.01). The Kaplan-Meier analysis revealed a poorer disease-free (P=0.022) and overall survival (P=0.013) in breast cancer patients expressing pERα-S118, but not in those expressing pERα-S167. In conclusion, pERα-S118 was correlated with the HER-2 status and predicted breast cancer resistance to tamoxifen.
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