Role of ROX index in the first assessment of COVID-19 patients in the emergency department.
Role of ROX index in the first assessment of COVID-19 patients in the emergency department.
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DOI：
10.1007/s11739-021-02675-2
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发表时间：
2021-10
影响因子：
4.6
通讯作者：
Giostra F
中科院分区：
文献类型：
--
作者：
Gianstefani A;Farina G;Salvatore V;Alvau F;Artesiani ML;Bonfatti S;Campinoti F;Caramella I;Ciordinik M;Lorusso A;Nanni S;Nizza D;Nava S;Giostra F
在2019冠状病毒病（COVID-19）第一次爆发期间，急诊科（EDs）人满为患。因此，需要一个快速和简单的工具来支持临床决策，如ROX指数（呼吸速率-氧合），定义为外周氧饱和度和吸入氧的比例，呼吸速率。本研究的目的是评估ROX指数在预测诊断为COVID-19的急诊科患者住院和死亡率方面的准确性。次要结局是评估再入院次数和第一次和第二次入院之间ROX指数的变化。这是一项观察性前瞻性单中心研究，在意大利博洛尼亚的Sant 'Orsola-Malpighi医院的急诊科进行。连续入组554例COVID-19患者，计算ROX指数。随访患者至出院或死亡。ROX指数< 25.7与住院相关（曲线下面积[AUC] = 0.737, 95% CI 0.696-0.779, p < 0.001）。ROX指数< 22.3与较高的30天死亡率有统计学相关性（AUC = 0.764, 95% CI 0.708 ~ 0.820, p < 0.001）。8例患者出院后7 d内返回急诊科，第一次评估时ROX指数平均值为30.3(6.2；范围21.9 ~ 39.4)，第二次评估时ROX指数平均值为24.6(5.5;14.5 ~ 29.5)，差异有统计学意义（p = 0.012）。ROX指数与实验室、影像学和临床结果一起，与COVID-19患者的住院需求、机械通气和死亡风险相关。
During the first outbreak of Coronavirus disease 2019 (COVID-19) Emergency Departments (EDs) were overcrowded. Hence, the need for a rapid and simple tool to support clinical decisions, such as the ROX index (Respiratory rate – OXygenation), defined as the ratio of peripheral oxygen saturation and fraction of inspired oxygen, to respiratory rate. The aim of the study was to evaluate the accuracy of the ROX index in predicting hospitalization and mortality in patients with a diagnosis of COVID-19 in the ED. The secondary outcomes were to assess the number of readmissions and the variations in the ROX index between the first and the second admission. This was an observational prospective monocentric study, carried out in the ED of Sant’Orsola-Malpighi Hospital in Bologna, Italy. Five hundred and fifty-four consecutive patients with COVID-19 were enrolled and the ROX index was calculated. Patients were followed until hospital discharge or death. A ROX index value < 25.7 was associated with hospitalization (area under the curve [AUC] = 0.737, 95% CI 0.696–0.779, p < 0.001). The ROX index < 22.3 was statistically related to higher 30-day mortality (AUC = 0.764, 95% CI 0.708–0.820, p < 0.001). Eight patients were discharged and returned to the ED within the subsequent 7 days, their mean ROX index was 30.3 (6.2; range 21.9–39.4) at the first assessment and 24.6 (5.5; 14.5–29.5) at the second assessment, (p = 0.012). The ROX index, together with laboratory, imaging and clinical findings, correlated with the need for hospital admission, mechanical ventilation and mortality risk in COVID-19 patients.
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影响因子：
8.1
作者：
Rodriguez, Maeva;Thille, Arnaud W.;Coudroy, Remi
通讯作者：
Coudroy, Remi
影响因子：
168.9
作者：
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通讯作者：
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DOI：
10.1164/rccm.201803-0589oc
发表时间：
2019-06-01
影响因子：
24.7
作者：
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影响因子：
158.5
作者：
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通讯作者：
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影响因子：
3.7
作者：
Mauri, Tommaso;Carlesso, Eleonora;Grasselli, Giacomo
通讯作者：
Grasselli, Giacomo