Permeation of herbicidal dichlobenil from a Casoron formulation through nitrile gloves.
Permeation of herbicidal dichlobenil from a Casoron formulation through nitrile gloves.
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DOI：
10.1007/s00244-009-9407-7
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发表时间：
2010-02
影响因子：
4
通讯作者：
Zainal, Hanaa
中科院分区：
文献类型：
--
作者：
Hee, Shane S. Que;Zainal, Hanaa
本研究的目的是使用美国测试和材料协会型渗透池和采用两种不同溶剂（己烷和水）和两种不同挑战情况（水乳液和固体制剂）的闭环系统，通过一次性化学防护丁腈手套测量 Casoron 4G 中除草剂敌草腈的渗透性。使用毛细管气相色谱-质谱法进行定量。对于固体制剂和水收集挑战，化学防护手套在长达 8 小时内不允许任何渗透，但在所有其他挑战中均检测到渗透。一次性手套允许最大程度的渗透，并且由于存在水解降解产物 2,6-二氯苯甲酰胺，因此收集水的固体制剂挑战需要计算敌菌腈当量。固体制剂的渗透可通过一次性手套和化学防护手套的己烷收集以及一次性手套的水收集来检测。结论是，相对于水收集溶剂数据，己烷溶剂收集对于固体 Casoron 挑战中渗透 4 和 8 小时的一次性手套或水乳液挑战 8 小时的渗透无效。化学防护手套的己烷溶剂收集对于 8 小时固体制剂挑战有效，但对于 8 小时水溶液挑战无效。所有水-溶剂集合均有效；然而，敌敌畏通常会渗透到手套中。
The aim of this study was to measure permeation of the herbicide dichlobenil in Casoron 4G through disposable and chemically protective nitrile gloves using an American Society for Testing and Materials-type permeation cell and a closed-loop system employing two different solvents (hexane and water) and two different challenge situations (aqueous emulsion and solid formulation). Capillary gas chromatography–mass spectrometry was used for quantification purposes. The chemically protective glove did not allow any permeation up to 8 h for the solid-formulation and water-collection challenges, but permeation was detected in all other challenges. The disposable glove allowed the most permeation, and the solid-formulation challenge with water collection necessitated that a dichlobenil equivalent be calculated because of the presence of its hydrolysis degradation product 2,6-dichlorobenzamide. Permeation from the solid formulation was detectable by hexane collection for both the disposable and chemically protective gloves and by water collection for the disposable glove. It was concluded that hexane-solvent collection was not valid for the disposable glove at 4 and 8 h of permeation in the solid Casoron challenge or for the aqueous emulsion challenge at 8 h relative to the water-collection solvent data. The hexane-solvent collection for the chemically protective glove was valid for the 8-h solid-formulation challenge but not for the 8-h aqueous-solution challenge. All water-solvent collections were valid; however, dichlobenil usually permeated the gloves.
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影响因子：
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