Guest-release control in enzyme-sensitive, amphiphilic-dendrimer-based nanoparticles through photochemical crosslinking.
Guest-release control in enzyme-sensitive, amphiphilic-dendrimer-based nanoparticles through photochemical crosslinking.
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DOI：
10.1002/chem.201101066
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发表时间：
2011-10-10
影响因子：
4.3
通讯作者：
Thayumanavan, S.
中科院分区：
文献类型：
--
作者：
Raghupathi, Krishna R.;Azagarsamy, Malar A.;Thayumanavan, S.
刺激敏感的、表面两亲性树枝状聚合物已经被合成，并且它们的酶响应性质已经通过共价结合和非共价结合的报告单元的双重荧光响应来确定。这些双重反应与确定酶作用对胶束聚集体的影响以及随之而来的客体释放相关。通过疏水性香豆素单元的光化学交联来稳定胶束聚集体，可以方便地调节客体分子的释放。这种光交联也被用作研究聚集体-单体平衡背景下酶-底物相互作用模式的工具。
Stimuli sensitive, facially amphiphilic dendrimers have been synthesized and their enzyme-responsive nature has been determined with dual fluorescence responses of both covalently conjugated and non-covalently bound reporter units. These dual responses are correlated to ascertain the effect of enzymatic action on micellar aggregates and the consequential guest release. The release of the guest molecule is conveniently tuned by stabilizing the micellar aggregates through photochemical crosslinking of hydrophobic coumarin units. This photo-crosslinking is also utilized as a tool to investigate the mode of enzyme-substrate interaction in the context of aggregate-monomer equilibrium.
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影响因子：
3.6
作者：
Azagarsamy, Malar A.;Krishnamoorthy, Kothandam;Thayumanavan, S.
通讯作者：
Thayumanavan, S.
影响因子：
15
作者：
Aathimanikandan, SV;Savariar, EN;Thayumanavan, S
通讯作者：
Thayumanavan, S
基于酸不稳定聚碳酸酯疏水物的 pH 响应型可生物降解胶束：合成和触发药物释放
影响因子：
6.2
作者：
Chen, Wei;Meng, Fenghua;Zhong, Zhiyuan
通讯作者：
Zhong, Zhiyuan
影响因子：
16.6
作者：
Babin, Jerome;Pelletier, Maxime;Zhao, Yue
通讯作者：
Zhao, Yue
影响因子：
16.6
作者：
de Groot, FMH;Albrecht, C;Scheeren, HW
通讯作者：
Scheeren, HW