Assimilation, distribution and toxicity of tetrabromobisphenol A to female Wistar rats through subchronic dermal exposure
Assimilation, distribution and toxicity of tetrabromobisphenol A to female Wistar rats through subchronic dermal exposure
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亚慢性皮肤接触四溴双酚 A 对雌性 Wistar 大鼠的同化、分布和毒性
DOI：
10.1016/j.ibiod.2017.09.016
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发表时间：
2017-09
影响因子：
4.8
通讯作者：
Hui Li
中科院分区：
文献类型：
--
作者：
Yunjiang Yu;Mingdeng Xiang;D;an Gao;Hao Ye;Qiong Wang;Yanping Zhang;Liangzhong Li;Hui Li
四溴双酚A（TBBPA）是一种应用最广泛的溴化阻燃剂，在环境和生物样品中经常被检测到。虽然已经就口服接触的健康影响和毒性进行了大量研究，但很少有人探索其他接触途径。在本研究中，TBBPA给药雌性Wistar大鼠90天，重复皮肤暴露在20，60，200和600毫克TBBPA/公斤体重，随后的血清，尿液和粪便中的浓度TBBPA进行了测定。血清中TBBPA浓度范围为38.26 - 115.9 μg/g脂质，尿液中为0.62 - 1.02 ng/μM肌酐，粪便中为288.22 - 1815.66 μg/g。TBBPA的皮肤吸收率为3.76%~ 13.40%，血液中的TBBPA含量相对较少。皮肤接触后，大部分TBBPA通过粪便排泄，而尿液中发现少量TBBPA。亚慢性皮肤接触TBBPA后，未观察到对动物生长或胸腺、心脏、肺、肝、肾、脾、卵巢和脑的器官系数的显著影响。此外，90天重复皮肤给药未在雌性Wistar大鼠中诱导可见的皮肤病理学病变。结果表明，TBBPA经皮肤暴露后主要通过粪便途径排出，血液中残留浓度较低，亚慢性皮肤暴露对动物的影响不明显。
Tetrabromobisphenol A (TBBPA) is one of the most widely used brominated flame retardants and is frequently detected in environmental and biological samples. While numerous studies have been conducted on the health effects and toxicokinetics upon oral exposure, few have explored other exposure routes. In the present study, TBBPA was administered to female Wistar rats for 90 days by repeated dermal exposure at 20, 60, 200 and 600 mg TBBPA/kg body weight, and subsequently the concentrations of TBBPA in serum, urine, and feces were determined. TBBPA concentration ranged between 38.26 and 115.9 μg/g lipid in serum, 0.62 and 1.02 ng/μM creatinine in urine, and 288.22 and 1815.66 μg/g in feces. Approximately 3.76–13.40% of the applied TBBPA were absorbed dermally and transported for distribution, but the amount of TBBPA detected in blood was relatively small. The majority of the TBBPA was excreted in feces after dermal exposure while small quantities of TBBPA were found in urine. No significant effects on animal growth or organ coefficients for the thymus, heart, lung, liver, kidneys, spleen, ovary, and brain were observed after subchronic dermal exposure to TBBPA. In addition, repeated dermal administration for 90 days did not induce visible skin pathologic lesions in the female Wistar rats. Our results show that the TBBPA via dermal exposure was mainly discharged through fecal route and residual concentration was low in blood, and the effects of TBBPA were not apparent in animals following subchronic dermal exposure.
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影响因子：
1.8
作者：
Hakk, H;Larsen, G;Örn, U
通讯作者：
Örn, U
DOI：
--
发表时间：
2009
期刊：
--
影响因子：
--
作者：
C. Boyce;Sonja N. Sax;D. Dodge;Margaret C. Pollock;J. Goodman
通讯作者：
C. Boyce;Sonja N. Sax;D. Dodge;Margaret C. Pollock;J. Goodman
DOI：
10.1016/j.ibiod.2015.12.004
发表时间：
2016-03-01
影响因子：
4.8
作者：
Lv, Yuancai;Li, Lianghao;Hu, Yongyou
通讯作者：
Hu, Yongyou
DOI：
10.1016/j.ibiod.2013.05.006
发表时间：
2013-11-01
影响因子：
4.8
作者：
Chou, Hsi-Ling;Chang, Yi-Tang;Lin, Ching-Hsing
通讯作者：
Lin, Ching-Hsing
DOI：
10.1016/j.ibiod.2013.10.011
发表时间：
2014-02-01
影响因子：
4.8
作者：
Huang, Huang-Wen;Chang, Bea-Ven;Lee, Ching-Chang
通讯作者：
Lee, Ching-Chang