Treating coronary disease and the impact of endothelial dysfunction.
Treating coronary disease and the impact of endothelial dysfunction.
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DOI：
10.1016/j.pcad.2014.10.004
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发表时间：
2015-03
影响因子：
9.1
通讯作者：
Lerman, Amir
中科院分区：
文献类型：
--
作者：
Matsuzawa, Yasushi;Guddeti, Raviteja R.;Kwon, Taek-Geun;Lerman, Lilach O.;Lerman, Amir
缺血性心脏病是全世界发病率和死亡率的主要原因。许多临床试验表明，生活方式和药物干预在减缓动脉粥样硬化疾病进展和事件发展方面是有效的。然而，仔细考虑全面的血管健康的个性化方法是必要的，以执行成功的干预策略。内皮功能障碍在动脉粥样硬化的早期阶段起着关键作用，也与斑块进展和动脉粥样硬化并发症的发生有关。内皮功能的评估为我们提供了关于个体患者风险、疾病进展和脆弱性以及治疗指导的重要信息。因此，内皮功能评估的应用可能使临床医生创新理想的个体化用药。本文就动脉粥样硬化性心血管疾病药物治疗对内皮功能的影响进行综述，并对无创性内皮功能评估的实用性进行探讨。
Ischemic heart disease is the leading cause of morbidity and mortality throughout the world. Many clinical trials have suggested that lifestyle and pharmacologic interventions are effective in attenuating atherosclerotic disease progression and events development. However, an individualized approach with careful consideration to comprehensive vascular health is necessary to perform successful intervention strategies. Endothelial dysfunction plays a pivotal role in the early stage of atherosclerosis and is also associated with plaque progression and occurrence of atherosclerotic complications. The assessment of endothelial function provides us with important information about individual patient risk, progress and vulnerability of disease, and guidance of therapy. Thus, the application of endothelial function assessment might enable clinicians to innovate ideal individualized medicine. In this review, we summarize the current knowledge on the impact of pharmacological therapies for atherosclerotic cardiovascular disease on endothelial dysfunction, and argue for the utility of non-invasive assessment of endothelial function aiming at individualized medicine.
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影响因子：
3.2
作者：
Bank, Alan J.;Kelly, Aaron S.;Gonzalez-Campoy, J. Michael
通讯作者：
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DOI：
10.1097/mco.0b013e3283439622
发表时间：
2011-03-01
影响因子：
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作者：
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通讯作者：
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影响因子：
37.8
作者：
Broeders, MAW;Doevendans, PA;van der Zee, R
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