Decrease of miR-202-3p expression, a novel tumor suppressor, in gastric cancer.
Decrease of miR-202-3p expression, a novel tumor suppressor, in gastric cancer.
复制标题
胃癌中新型肿瘤抑制因子 miR-202-3p 表达的减少
DOI：
10.1371/journal.pone.0069756
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zhu Z
中科院分区：
文献类型：
--
作者：
Zhao Y;Li C;Wang M;Su L;Qu Y;Li J;Yu B;Yan M;Yu Y;Liu B;Zhu Z
Emerging studies have indicated that microRNAs are involved in the development and progression of cancer. Here we found that miR-202-3p was frequently down-regulated in gastric cancer tissues. Overexpression of miR-202-3p in gastric cancer cells MKN-28 and BGC-823, markedly suppressed cell proliferation and induced cell apoptosis both in vitro and in vivo. Furthermore, Gli1 expression was frequently positive in gastric cancer tissues and inversely correlated with miR-133b expression. We demonstrate that the transcriptional factor Gli1 was a target of miR-202-3p and plays an essential role as a mediator of the biological effects of miR-202-3p in gastric cancer. MiR-202-3p also inhibited the expression of γ-catenin and BCL-2. Taken together, these findings suggest that miR-202-3p may function as a novel tumor suppressor in gastric cancer and its anti-tumor activity may attribute the direct targeting and inhibition of Gli1.
登录
查看更多内容
DOI：
10.1158/1055-9965.epi-12-1131-t
发表时间：
2013-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Hoffman AE;Liu R;Fu A;Zheng T;Slack F;Zhu Y
通讯作者：
Zhu Y
miR-181b 和 miR-21 在接受 S-1/奥沙利铂或多西氟尿苷/奥沙利铂治疗的胃癌患者中的预后意义
影响因子：
3.7
作者：
Jiang J;Zheng X;Xu X;Zhou Q;Yan H;Zhang X;Lu B;Wu C;Ju J
通讯作者：
Ju J
影响因子：
64.5
作者：
Hafner M;Landthaler M;Burger L;Khorshid M;Hausser J;Berninger P;Rothballer A;Ascano M Jr;Jungkamp AC;Munschauer M;Ulrich A;Wardle GS;Dewell S;Zavolan M;Tuschl T
通讯作者：
Tuschl T
影响因子：
4.8
作者：
Ji, Zhenyu;Mei, Fang C.;Cheng, Xiaodong
通讯作者：
Cheng, Xiaodong
影响因子：
11.2
作者：
Iorio, MV;Ferracin, M;Croce, CM
通讯作者：
Croce, CM