The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques.
The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques.
复制标题
DOI：
10.1038/ni.2205
复制
发表时间：
2012-01-08
影响因子：
30.5
通讯作者：
中科院分区：
文献类型：
--
作者：
Atherosclerotic plaque formation is fueled by the persistence of lipid-laden macrophages in the artery wall. The mechanisms by which these cells become trapped, thereby establishing chronic inflammation, remain unknown. Netrin-1, a neuroimmune guidance cue, was secreted by macrophages in human and mouse atheroma, where it inactivated macrophage migration to chemokines implicated in their egress from plaques. Acting via its receptor UNC5b, netrin-1 inhibited CCL2- and CCL19-directed macrophage migration, Rac1 activation and actin polymerization. Targeted deletion of netrin-1 in macrophagesseverely diminished atherosclerosis progression in Ldlr−/− mice and promoted macrophage emigration from plaques. Thus, netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall and establish a causative role for negative regulators of leukocyte migration in chronic inflammation.
登录
查看更多内容
影响因子：
64.5
作者：
Moore KJ;Tabas I
通讯作者：
Tabas I
具有遗传转换的高脂血症的逆转会影响动脉粥样硬化斑块中巨噬细胞的含量和炎症状态。
影响因子：
37.8
作者：
Feig JE;Parathath S;Rong JX;Mick SL;Vengrenyuk Y;Grauer L;Young SG;Fisher EA
通讯作者：
Fisher EA
DOI：
10.1084/jem.20011794
发表时间：
2002-12-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bellingan GJ;Xu P;Cooksley H;Cauldwell H;Shock A;Bottoms S;Haslett C;Mutsaers SE;Laurent GJ
通讯作者：
Laurent GJ
影响因子：
15.9
作者：
Feig, Jonathan E.;Pineda-Torra, Ines;Fisher, Edward A.
通讯作者：
Fisher, Edward A.
影响因子：
16.2
作者：
Keleman, K;Dickson, BJ
通讯作者：
Dickson, BJ