The association between the levels of serum ferritin and sex hormones in a large scale of Chinese male population.
The association between the levels of serum ferritin and sex hormones in a large scale of Chinese male population.
复制标题
中国大量男性人群血清铁蛋白水平与性激素的关联。
DOI：
10.1371/journal.pone.0075908
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Mo Z
中科院分区：
文献类型：
--
作者：
Liu Z;Ye F;Zhang H;Gao Y;Tan A;Zhang S;Xiao Q;Zhang B;Huang L;Ye B;Qin X;Wu C;Lu Z;Zhang Y;Liao M;Yang X;Mo Z
铁蛋白是铁储存的重要参与者，但其调控及相关因素尚不清楚。本研究的目的是探讨血清铁蛋白水平与性激素之间的潜在关系。采用横断面研究方法，对1999年防城港地区男性健康与体检调查（FAMHES）中的男性进行了调查。检测血清铁蛋白、总睾酮（游离睾酮由总睾酮计算）、雌二醇和性激素结合蛋白水平。分别分析年龄、BMI、吸烟和饮酒对铁蛋白水平的影响，然后用Pearson相关分析评估铁蛋白水平与调整上述因素后的性激素之间的关系。年龄、体重指数、饮酒量对血清铁蛋白水平有显著影响，但吸烟者与不吸烟者之间无显著差异。铁蛋白水平与总睾酮（R =-0.205，P< 0.001）、性激素结合蛋白（R =-0.161，P<0.001）和游离睾酮（R =-0.097，P<0.001）呈显著负相关。 在调整年龄和饮酒量后，上述相关性仍然显著（R分别为-0.200、-0.181和-0.083，P均<0.001）。 然而，铁蛋白水平和雌二醇之间只有临界负相关（校正后的R =-0.039，P = 0.083）。 大规模的流行病学调查结果显示，血清铁蛋白水平与性激素水平呈显著负相关，这可能为探讨铁蛋白的潜在调节作用及其生物学机制提供更多线索。
The ferritin is an important participant of iron-storage but its regulation and related factors were not well defined. The present objective was to explore the potential association between serum ferritin levels and sex hormones. 1999 Chinese men in the Fangchenggang Area Male Health and Examination Survey (FAMHES) were recruited in this cross-sectional study. Levels of serum ferritin, total testosterone (free testosterone was calculated from the total one), estradiol and sex hormone-binding protein were detected in venous blood samples. The effects of age, BMI, smoking as well as alcohol consumption were analyzed on ferritin levels, respectively, and then the Pearson’s correlation analysis was used to evaluate the association between ferritin levels and sex hormones adjusting for the above factors. The age, BMI and alcohol consumption significantly affected serum ferritin levels, but there was no significant difference between smokers and nonsmokers. Ferritin levels were significantly and negatively associated with total testosterone (R = −0.205, P< 0.001), sex hormone-binding protein (R = −0.161, P<0.001) and free testosterone (R = −0.097, P<0.001). After age and alcohol consumption were adjusted, the above associations were still significant (R = −0.200, −0.181 and −0.083, respectively, all P<0.001). However, there was only borderline negative association between ferritin levels and estradiol (adjusted R = −0.039, P = 0.083). The large scale of epidemic results showed the significantly negative associations between serum ferritin levels and sex hormones, which may provide more clues to explore the potential regulation and biological mechanism of ferritin.
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影响因子：
3.7
作者：
Chen G;Li S;Dong X;Bai Y;Chen A;Yang S;Fang M;Zamaratskaia G;Doran O
通讯作者：
Doran O
影响因子：
5
作者：
JONES, BM;WORWOOD, M;JACOBS, A
通讯作者：
JACOBS, A
影响因子：
13.2
作者：
Brockenbrough, AT;Dittrich, MO;Bremner, WJ
通讯作者：
Bremner, WJ
影响因子：
2.3
作者：
Kemna, Erwin H. J. M.;Kartikasari, April E. R.;Swinkels, Dorine W.
通讯作者：
Swinkels, Dorine W.
DOI：
10.1152/ajpendo.90940.2008
发表时间：
2009-06-01
影响因子：
5.1
作者：
Gonzales, Gustavo F.;Gasco, Manuel;Gonzales-Castaneda, Cynthia
通讯作者：
Gonzales-Castaneda, Cynthia