The Circadian Basis of Ovarian Diapause Regulation in Drosophila melanogaster: Is the period Gene Causally Involved in Photoperiodic Time Measurement?
The Circadian Basis of Ovarian Diapause Regulation in Drosophila melanogaster: Is the period Gene Causally Involved in Photoperiodic Time Measurement?
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果蝇卵巢滞育调节的昼夜节律基础：周期基因是否与光周期时间测量有因果关系？
DOI：
10.1177/074873049000500404
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发表时间：
1990
影响因子：
3.5
通讯作者：
D. Saunders
中科院分区：
文献类型：
--
作者：
D. Saunders
野生型黑腹果蝇(广州-S)和几个时钟突变体(Period)的雌性能够区分诱导滞育的短日和避免滞育的长日，并具有明确的临界日长。短周期突变体(PerS)和长周期突变体(PerL2)的临界日长几乎相同，无论是彼此还是与广州-S的临界日长都是如此。然而，心律失常突变体(PEROL)的临界日长比广州-S短约3小时，而Per-的临界日长则短约5小时。对广州-S雌虫进行的南达-哈姆纳实验表明，(1)黑腹金龟的光周期时钟测量的是夜间长度而不是白天长度，(2)光周期时间测量的某种程度上是基于昼夜节律系统中的成分振荡器(或受其影响)。南达-哈姆纳实验包括10小时的光相与4至74小时的暗相。Nanda-Hamner对这两个时期突变体的结果都显示出相似的图谱，无论是不同的基因型，或者是否存在每一位点的DNA。这些结果表明，光周期诱导和运动活动在黑腹果蝇中并不共享一个共同的起搏器，并且per基因与光周期时钟测量夜间长度没有因果关系，尽管per基因缺失(per-)或缺陷(Perol)的果蝇显示出一个改变的临界值。
Females of a wild-type strain of Drosophila melanogaster (Canton-S), and of several clock mutants (period), were able to discriminate between diapause-inducing short days and diapause- averting long days with a well-defined critical daylength. The critical daylengths of a short-period mutant (pers ) and a long-period mutant (perL2 ) were almost identical, both to each other and to that of Canton-S. The critical daylength of an arrhythmic mutant (perol ), however, was about 3 hr shorter than that of Canton-S, and that of per- was about 5 hr shorter. Exposure of Canton-S females to Nanda-Hamner experiments, consisting of a 10-hr photophase coupled to a dark phase varying between 4 and 74 hr, showed (1) that the photoperiodic clock in D. melanogaster measures nightlength rather than daylength, and (2) that photoperiodic time measurement is somehow based on (or affected by) constituent oscillators in the circadian system. Nanda-Hamner results for the period mutants all showed similar profiles regardless of genotype, or the presence or absence of per locus DNA. These results suggest that photoperiodic induction and locomotor activity do not share a common pacemaker in D. melanogaster, and that the per gene is not causally involved in nightlength measurement by the photoperiodic clock, although flies in which the per locus is missing (per-) or defective (perol ) show an altered critical value.
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DOI：
10.1073/pnas.84.3.784
发表时间：
1987-02
影响因子：
11.1
作者：
Q. Yu;A. Jacquier;Y. Citri;M. Hamblen;J. C. Hall;M. Rosbash
通讯作者：
Q. Yu;A. Jacquier;Y. Citri;M. Hamblen;J. C. Hall;M. Rosbash
影响因子：
1.9
作者：
HAMBLENCOYLE, M;KONOPKA, RJ;HALL, JC
通讯作者：
HALL, JC
DOI：
10.1073/pnas.86.10.3748
发表时间：
1989-05-01
影响因子：
11.1
作者：
SAUNDERS, DS;HENRICH, VC;GILBERT, LI
通讯作者：
GILBERT, LI
影响因子：
1.9
作者：
HAMBLEN, M;ZEHRING, WA;HALL, JC
通讯作者：
HALL, JC