A circulating subpopulation of monocytic myeloid-derived suppressor cells as an independent prognostic/predictive factor in untreated non-small lung cancer patients.
A circulating subpopulation of monocytic myeloid-derived suppressor cells as an independent prognostic/predictive factor in untreated non-small lung cancer patients.
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DOI：
10.1155/2014/659294
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发表时间：
2014
影响因子：
4.1
通讯作者：
Kotsakis A
中科院分区：
文献类型：
--
作者：
Vetsika EK;Koinis F;Gioulbasani M;Aggouraki D;Koutoulaki A;Skalidaki E;Mavroudis D;Georgoulias V;Kotsakis A
骨髓源性抑制细胞（MDSC）代表了具有免疫抑制特性的异质性细胞群，并可能导致癌症患者的预后不良。在非小细胞肺癌（NSCLC）患者中研究了表型上新描述的MDSC亚群的存在及其与临床结局的相关性。采用流式细胞术研究了110例化疗初治患者和健康对照者外周血中MDSC和不同免疫细胞的百分比及其相关性。两个单核细胞[CD 14 + CD 15 − CD 11b + CD 33 +HLA-DR−Lin−和CD 14 + CD 15 + CD 11b + CD 33 +HLA-DR−Lin−]和粒细胞[CD 14 − CD 15 + CD 11b + CD 33 +HLA-DR−Lin−] MDSC亚群分别表达诱导型一氧化氮合酶和活性氧。两种单核细胞-MDSC亚群百分比的增加与树突状细胞/单核细胞水平呈负相关（P ≤ 0.04），而粒细胞-MDSC与CD 4 + T细胞呈负相关（P = 0.006）。单核细胞-MDSC百分比增加与治疗反应较差相关（P = 0.02），与高水平患者相比，CD 14 + CD 15 + CD 11b + CD 33 +HLA-DR−Lin−水平正常的患者总生存期和无进展生存期较长（分别为P = 0.008和P = 0.005）。多变量分析显示，CD 14 + CD 15 + CD 11b + CD 33 +HLA-DR−Lin− MDSC百分比的增加与无进展生存期和总生存期的降低独立相关。数据提供的证据表明，晚期NSCLC患者中新的单核细胞-MDSC亚群的百分比增加与不利的临床结局相关。
Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of cells with immunosuppressive properties and might confer to worse prognosis in cancer patients. The presence of phenotypically newly described subpopulations of MDSCs and their association with the clinical outcome were investigated in non-small cell lung cancer (NSCLC) patients. The percentages and correlation between MDSCs and distinct immune cells in the peripheral blood of 110 chemotherapy-naive patients before treatment and healthy controls were investigated using flow cytometry. Two monocytic [CD14+CD15−CD11b+CD33+HLA-DR−Lin− and CD14+CD15+CD11b+CD33+HLA-DR−Lin−] and a granulocytic [CD14−CD15+CD11b+CD33+HLA-DR−Lin−] subpopulations of MDSCs were identified, expressing inducible nitric oxide synthase, and reactive oxygen species, respectively. Increased percentages of both monocytic-MDSCs' subpopulations were inversely correlated to dendritic/monocyte levels (P ≤ 0.04), while granulocytic-MDSCs were inversely correlated to CD4+ T cells (P = 0.006). Increased percentages of monocytic-MDSCs were associated with worse response to treatment (P = 0.02) and patients with normal levels of CD14+CD15+CD11b+CD33+HLA-DR−Lin− had longer overall survival and progression free-survival compared to those with high levels (P = 0.008 and P = 0.005, resp.). Multivariate analysis revealed that the increased percentages of CD14+CD15+CD11b+CD33+HLA-DR−Lin− MDSCs were independently associated with decreased progression free-survival and overall survival. The data provide evidence that increased percentages of new monocytic-MDSCs' subpopulations in advanced NSCLC patients are associated with an unfavourable clinical outcome.
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癌症扩增的骨髓源性抑制细胞通过膜结合 TGF-β1 诱导 NK 细胞无反应。
影响因子：
4.4
作者：
Li, Hequan;Han, Yanmei;Cao, Xuetao
通讯作者：
Cao, Xuetao
影响因子：
4.4
作者：
Almand, B;Clark, JI;Gabrilovich, DI
通讯作者：
Gabrilovich, DI
影响因子：
20.3
作者：
Movahedi, Kiavash;Guilliams, Martin;Van Ginderachter, Jo A.
通讯作者：
Van Ginderachter, Jo A.
影响因子：
11.2
作者：
Rodriguez PC;Ernstoff MS;Hernandez C;Atkins M;Zabaleta J;Sierra R;Ochoa AC
通讯作者：
Ochoa AC
DOI：
10.1084/jem.20080132
发表时间：
2008-09-29
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cheng P;Corzo CA;Luetteke N;Yu B;Nagaraj S;Bui MM;Ortiz M;Nacken W;Sorg C;Vogl T;Roth J;Gabrilovich DI
通讯作者：
Gabrilovich DI