Quantitative muscle strength assessment in duchenne muscular dystrophy: longitudinal study and correlation with functional measures.
Quantitative muscle strength assessment in duchenne muscular dystrophy: longitudinal study and correlation with functional measures.
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DOI：
10.1186/1471-2377-12-91
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发表时间：
2012-09-13
期刊：
影响因子：
2.6
通讯作者：
Torrente Y
中科院分区：
文献类型：
--
作者：
Lerario A;Bonfiglio S;Sormani M;Tettamanti A;Marktel S;Napolitano S;Previtali S;Scarlato M;Natali-Sora M;Mercuri E;Bresolin N;Mongini T;Comi G;Gatti R;Ciceri F;Cossu G;Torrente Y
本研究的目的是使用定量肌肉测试（QMT）进行纵向评估，在一个队列的非卧床男孩受杜氏肌营养不良症（DMD），并将QMT的结果与功能措施。这项研究是迄今为止在DMD患者队列中对QMT进行的最彻底的长期评价，与其他测量方法相关，如北星星动态评估（NSAA）或6分钟步行试验（6 MWT）。这是一项单中心、前瞻性、非随机研究，在28名5至12岁的非卧床DMD男孩的研究队列中使用Kin Com® 125机器评估QMT。在12个月内对该队列进行纵向评估，包括3个月一次的QMT评估和功能能力评估，使用基线时和仅12个月时的NSAA和6 MWT。QMT也用于对照组13名健康的年龄匹配的男孩在基线和12个月检查。在12个月内，年龄低于7.5岁的男孩的QMT增加，而年龄高于7.5岁的男孩的QMT显着下降。所有平均一年变化均与健康对照组所经历的变化显着不同。我们还发现定量测试和其他测量之间有很好的相关性，这在强壮的孩子身上更明显。我们在DMD患者队列中使用QMT的纵向数据表明，这可以用作监测变化的额外工具，提供节段强度的额外信息。
The aim of this study was to perform a longitudinal assessment using Quantitative Muscle Testing (QMT) in a cohort of ambulant boys affected by Duchenne muscular dystrophy (DMD) and to correlate the results of QMT with functional measures. This study is to date the most thorough long-term evaluation of QMT in a cohort of DMD patients correlated with other measures, such as the North Star Ambulatory Assessment (NSAA) or thee 6-min walk test (6MWT). This is a single centre, prospective, non-randomised, study assessing QMT using the Kin Com® 125 machine in a study cohort of 28 ambulant DMD boys, aged 5 to 12 years. This cohort was assessed longitudinally over a 12 months period of time with 3 monthly assessments for QMT and with assessment of functional abilities, using the NSAA and the 6MWT at baseline and at 12 months only. QMT was also used in a control group of 13 healthy age-matched boys examined at baseline and at 12 months. There was an increase in QMT over 12 months in boys below the age of 7.5 years while in boys above the age of 7.5 years, QMT showed a significant decrease. All the average one-year changes were significantly different than those experienced by healthy controls. We also found a good correlation between quantitative tests and the other measures that was more obvious in the stronger children. Our longitudinal data using QMT in a cohort of DMD patients suggest that this could be used as an additional tool to monitor changes, providing additional information on segmental strength.
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影响因子：
3.1
作者：
Buyse, Gunnar M.;Goemans, Nathalie;Escolar, Diana M.
通讯作者：
Escolar, Diana M.
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Mercuri, Eugenio
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通讯作者：
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影响因子：
3.4
作者：
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通讯作者：
Swash, M