Antitussive activity of Pseudostellaria heterophylla (Miq.) Pax extracts and improvement in lung function via adjustment of multi-cytokine levels.
Antitussive activity of Pseudostellaria heterophylla (Miq.) Pax extracts and improvement in lung function via adjustment of multi-cytokine levels.
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DOI：
10.3390/molecules16043360
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发表时间：
2011-04-19
期刊：
影响因子：
--
通讯作者：
Hu J
中科院分区：
文献类型：
--
作者：
Pang W;Lin S;Dai Q;Zhang H;Hu J
太子参（Miq.）Pax是中国最广泛使用的草药和保健品之一。广泛的临床应用表明，它具有“益气生唾液，润肺止咳”的功能。从太子参根部提取的乙酸乙酯部位止咳效果在100 ~ 500 mg/kg之间呈剂量依赖性。在400mg /kg剂量下，乙酸乙酯部位能显著延长柠檬酸致咳豚鼠模型的咳嗽潜伏期，减少咳嗽次数。慢性阻塞性肺疾病稳定期模型大鼠肺气道阻力下降，动态肺顺应性升高，血清IL-8、GM-CSF、TNF-α、ET-1水平降低。上述结果提示乙酸乙酯部位的止咳作用与其通过调节多种细胞因子的水平来减轻气道炎症，从而改善肺功能有关。
Pseudostellaria heterophylla (Miq.) Pax is one of the most widespread herbal and healthcare products in China. Extensive clinical use has shown that it has functions which “strengthens qi and generates saliva, moistens the lung and relieves cough”. The ethyl acetate fraction extracted from the roots of the plant Pseudostellaria heterophylla exhibited a dose-dependent antitussive effect between 100 to 500 mg/kg. At a dose of 400 mg/kg, the ethyl acetate fraction treatment markedly prolonged the cough latent period and reduced the number of coughs in a guinea pig model induced by citric acid. Fall lung airway resistance, rise in dynamic lung compliance, decreased serum levels of IL-8, GM-CSF, TNF-α, and ET-1 in rat model of stable phase chronic obstructive pulmonary disease induced by cigarette smoke exposure were also observed. These results suggest that ethyl acetate fraction has antitussive activity related to its improvement in lung function via attenuation of airway inflammation by adjustment of multi-cytokine levels.
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