Total Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer
Total Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer
复制标题
局部晚期直肠癌的整体新辅助治疗与标准治疗
作者：
A. Kasi;Saqib Abbasi;S. Handa;R. Al;A. Saeed;J. Baranda;Weijing Sun
与标准同步放化疗后手术和辅助化疗（CRT + A）相比，局部晚期直肠癌的完全新辅助治疗（TNT）是否与改善结局相关？结果在这项系统性综述和荟萃分析的7个独特的研究，包括2416独特的患者，TNT被发现与标准CRT加A的方法相比，实现病理完全缓解和无病生存率显着较高。两种方法之间的保肛手术或回肠造口术要求率无显著差异。与标准CRT加A策略相比，局部晚期直肠癌的完全新辅助治疗与病理完全缓解率的改善相关，并且具有潜在的无病生存优势。
Key Points Question Is total neoadjuvant therapy (TNT) associated with improved outcomes when compared with standard concurrent chemoradiotherapy followed by surgery and adjuvant chemotherapy (CRT plus A) for locally advanced rectal cancer? Findings In this systematic review and meta-analysis of 7 unique studies including 2416 unique patients, TNT was found to be associated with a significantly higher rate of achieving a pathologic complete response and disease-free survival compared with the standard CRT plus A approach. No significant difference was found in rates of sphincter-preserving surgery or ileostomy requirements between the 2 approaches. Meaning Total neoadjuvant therapy was associated with improved pathologic complete response rates and has a potential disease-free survival advantage compared with the standard CRT plus A strategy in locally advanced rectal cancer.
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DOI：
10.6004/jnccn.2018.0061
发表时间：
2018-07
期刊：
Journal of the National Comprehensive Cancer Network : JNCCN
影响因子：
--
作者：
Benson AB;Venook AP;Al-Hawary MM;Cederquist L;Chen YJ;Ciombor KK;Cohen S;Cooper HS;Deming D;Engstrom PF;Grem JL;Grothey A;Hochster HS;Hoffe S;Hunt S;Kamel A;Kirilcuk N;Krishnamurthi S;Messersmith WA;Meyerhardt J;Mulcahy MF;Murphy JD;Nurkin S;Saltz L;Sharma S;Shibata D;Skibber JM;Sofocleous CT;Stoffel EM;Stotsky-Himelfarb E;Willett CG;Wuthrick E;Gregory KM;Gurski L;Freedman-Cass DA
通讯作者：
Freedman-Cass DA
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
9
作者：
Hasan S;Renz P;Wegner RE;Finley G;Raj M;Monga D;McCormick J;Kirichenko A
通讯作者：
Kirichenko A
影响因子：
51.1
作者：
Bosset, Jean-Francois;Calais, Gilles;Collette, Laurence
通讯作者：
Collette, Laurence