Regional relation between skin blood flow and sweating to passive heating and local administration of acetylcholine in young, healthy humans.
Regional relation between skin blood flow and sweating to passive heating and local administration of acetylcholine in young, healthy humans.
复制标题
年轻健康人群皮肤血流量和出汗与被动加热和乙酰胆碱局部给药之间的区域关系。
DOI：
10.1152/ajpregu.00514.2012
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Alexander,LacyM
中科院分区：
文献类型：
--
作者：
Smith,CarolineJ;Kenney,WLarry;Alexander,LacyM
人体出汗的区域差异已被广泛认识，但血管舒缩反应的差异和引起这种差异的机制仍不清楚。本研究旨在探讨年轻健康受试者对热刺激和药理学刺激的局部出汗率（RSR）和皮肤血流量（SkBF）反应之间的关系。9例（23±3岁）患者将皮内微透析（MD）探针插入前臂腹侧、腹部、大腿和下背部，并灌注乳酸林格液。使用通风胶囊测量每个MD膜上的RSR，每个胶囊内装有激光多普勒探头，用于测量红细胞通量（激光多普勒通量，LDF）作为SkBF的指标。受试者完成全身加热方案，口腔温度升高1°C，乙酰胆碱剂量反应（ACh 1 × 10−7-0.1 M，平均皮肤温度34°C）。在两种方案（50 mM硝普钠）结束时获得最大LDF。在加热过程中，不同部位的RSR差异较大（P< 0.0001），背部的RSR大于其他部位（P< 0.05），但LDF在不同部位之间相似（P= 0.343）。RSR与SkBF在加热初期（上肢：r= 0.77±0.09，大腿：r= 0.81±0.08，腹部：r= 0.89±0.04，背部：r= 0.86±0.04）表现出较强的相关性，但在加热后期无显著相关性。各组间RSR （P= 0.160）和SkBF （LDF，P= 0.841）无显著差异。综上所述，这些数据表明，SkBF的增加对于启动和增加出汗是必要的，但RSR的进一步上升并不完全依赖于SkBF的剂量-反应方式。此外，RSR不能用胆碱能敏感性或SkBF变异来解释。
Regional variation in sweating over the human body is widely recognized yet variation in vasomotor responses and mechanisms causing this variation remain unclear. This study aimed to explore the relation between regional sweating rates (RSR) and skin blood flow (SkBF) responses to thermal and pharmacological stimuli in young, healthy subjects. In nine subjects (23 ± 3 yr), intradermal microdialysis (MD) probes were inserted into the ventral forearm, abdomen, thigh, and lower back and perfused with lactated Ringer solution. RSR over each MD membrane were measured using ventilated capsules with a laser Doppler probe housed in each capsule for measurement of red cell flux (laser Doppler flux, LDF) as an index of SkBF. Subjects completed a whole body heating protocol to 1°C rise in oral temperature and an acetylcholine dose response (ACh 1 × 10−7-0.1 M; mean skin temperature 34°C). Maximal LDF were obtained at the end of both protocols (50 mM sodium nitroprusside).During heating RSR varied among sites (P< 0.0001) and was greater on the back versus other sites (P< 0.05), but LDF was similar between sites (P= 0.343). RSR and SkBF showed a strong relation during initial (arm:r= 0.77 ± 0.09, thigh:r= 0.81 ± 0.08, abdomen:r= 0.89 ± 0.04, back:r= 0.86 ± 0.04) but not latter stages of heating. No differences in RSR (P= 0.160) or SkBF (LDF,P= 0.841) were observed between sites during ACh perfusion. Taken together, these data suggest that increases in SkBF are necessary to initiate and increase sweating, but further rises in RSR are not fully dependent on SkBF in a dose-response manner. Furthermore, RSR cannot be explained by cholinergic sensitivity or variation in SkBF.
登录
查看更多内容
囊性纤维化、血管活性肠多肽和活性皮肤血管舒张。
DOI：
10.1152/jappl.1990.69.6.2149
发表时间：
1990
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Savage,MV;Brengelmann,GL;Buchan,AM;Freund,PR
通讯作者：
Freund,PR
DOI：
10.1113/jphysiol.1959.sp006310
发表时间：
1959
期刊：
The Journal of Physiology
影响因子：
--
作者：
K. Collins;F. Sargent;J. Weiner
通讯作者：
J. Weiner
运动引起的高热期间出汗阈值降低。
DOI：
10.1007/bf00386153
发表时间：
1995
期刊：
Pflugers Archiv : European journal of physiology
影响因子：
--
作者：
Lopez,M;Sessler,DI;Walter,K;Emerick,T;Ayyalapu,A
通讯作者：
Ayyalapu,A
药理学曲线拟合分析皮肤肾上腺素能反应。
DOI：
10.1152/japplphysiol.00780.2011
发表时间：
2011
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Wenner,MeganM;Wilson,ThadE;Davis,ScottL;Stachenfeld,NinaS
通讯作者：
Stachenfeld,NinaS
身体发热时出汗与前臂血管舒张的关系
DOI：
10.1113/jphysiol.1962.sp006918
发表时间：
1962
期刊：
The Journal of Physiology
影响因子：
--
作者：
A. Love;R. Shanks
通讯作者：
R. Shanks