Dissecting the Vesicular Trafficking Function of IFT Subunits

Dissecting the Vesicular Trafficking Function of IFT Subunits
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剖析 IFT 亚基的囊泡运输功能

DOI:
10.3389/fcell.2019.00352
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发表时间:
2020-01
影响因子:
5.5
通讯作者:
Kaiyao Huang
Kaiyao Huang
中科院分区:
生物学2区
文献类型:
--
作者:
Huihui Yang;Kaiyao Huang

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鞭毛内转运(IFT)最初被认为是一种由多个蛋白质亚基组成的转运机器,它在纤毛/鞭毛的组装、拆卸和维持中起着至关重要的作用,是细胞外信号整合到细胞内信号的纽带。到目前为止,除了它在纤毛细胞中的成熟和不可或缺的作用,大多数IFT亚基在非纤毛细胞中表现出更一般的囊泡运输功能。本文就IFT亚基在囊泡转运中的作用进行综述,并对今后的研究提出建议。
Intraflagellar transport (IFT) was initially identified as a transport machine with multiple protein subunits, and it is essential for the assembly, disassembly, and maintenance of cilium/flagellum, which serves as the nexus of extracellular-to-intracellular signal integration. To date, in addition to its well-established and indispensable roles in ciliated cells, most IFT subunits have presented more general functions of vesicular trafficking in the non-ciliated cells. Thus, this review aims to summarize the recent progress on the vesicular trafficking functions of the IFT subunits and to highlight the issues that may arise in future research.
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