The ageing kidney: Molecular mechanisms and clinical implications.
The ageing kidney: Molecular mechanisms and clinical implications.
复制标题
DOI：
10.1016/j.arr.2020.101151
复制
发表时间：
2020-11
影响因子：
13.1
通讯作者：
Gong R
中科院分区：
文献类型：
--
作者：
Fang Y;Gong AY;Haller ST;Dworkin LD;Liu Z;Gong R
随着人类预期寿命的不断增加，人口老龄化对临床实践提出了越来越大的挑战。人类衰老与包括肾脏在内的多种器官系统的分子、结构和功能变化有关。在衰老过程中，肾脏经历进行性功能衰退以及宏观和微观组织学改变，而高血压和糖尿病等全身性合并症，或先前存在或潜在的肾脏疾病，会加剧这种变化。虽然衰老本身不会造成肾脏损伤，但与正常衰老过程相关的生理变化可能损害肾脏的修复能力，从而使老年人易患急性肾病、慢性肾病和其他肾脏疾病。从机制上讲，细胞衰老在肾脏衰老中起着关键作用，涉及许多细胞信号传导机制，其中许多可能被用作减缓甚至逆转肾脏衰老的干预靶点。本文综述了肾脏衰老的临床特点，重点介绍了细胞衰老在肾脏衰老中的作用的最新进展，并展望了预防或改善肾脏衰老的潜在干预策略和新的治疗靶点，以期在整个生命过程中维持肾脏的长期健康和功能。
As human life expectancy keeps increasing, ageing populations present a growing challenge for clinical practices. Human ageing is associated with molecular, structural, and functional changes in a variety of organ systems, including the kidney. During the ageing process, the kidney experiences progressive functional decline as well as macroscopic and microscopic histological alterations, which are accentuated by systemic comorbidities like hypertension and diabetes mellitus, or by preexisting or underlying kidney diseases. Although ageing per se does not cause kidney injury, physiologic changes associated with normal ageing processes are likely to impair the reparative capacity of the kidney and thus predispose older people to acute kidney disease, chronic kidney disease and other renal diseases. Mechanistically, cell senescence plays a key role in renal ageing, involving a number of cellular signaling mechanisms, many of which may be harnessed as interventional targets for slowing or even reversing kidney ageing. This review summarizes the clinical characteristics of renal ageing, highlights the latest progresses in deciphering the role of cell senescence in renal ageing, and envisages potential interventional strategies and novel therapeutic targets for preventing or improving renal ageing in the hope of maintaining long-term kidney health and function across the life course.
登录
查看更多内容
DOI：
10.2215/cjn.04160511
发表时间：
2011-12-01
影响因子：
9.8
作者：
Berger, Jonathan C.;Muzaale, Abimereki D.;Segev, Dorry L.
通讯作者：
Segev, Dorry L.
影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
DOI：
10.1056/nejmoa1306033
发表时间：
2013-12-26
期刊：
The New England journal of medicine
影响因子：
--
作者：
de Zeeuw D;Akizawa T;Audhya P;Bakris GL;Chin M;Christ-Schmidt H;Goldsberry A;Houser M;Krauth M;Lambers Heerspink HJ;McMurray JJ;Meyer CJ;Parving HH;Remuzzi G;Toto RD;Vaziri ND;Wanner C;Wittes J;Wrolstad D;Chertow GM;BEACON Trial Investigators
通讯作者：
BEACON Trial Investigators
影响因子：
4.8
作者：
de Cavanagh, EMV;Piotrkowski, B;Fraga, CG
通讯作者：
Fraga, CG