Immunomodulatory and anti-inflammatory effects of chondroitin sulphate.
Immunomodulatory and anti-inflammatory effects of chondroitin sulphate.
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DOI：
10.1111/j.1582-4934.2009.00826.x
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发表时间：
2009-08
影响因子：
5.3
通讯作者：
Montell E
中科院分区：
文献类型：
--
作者：
du Souich P;García AG;Vergés J;Montell E
硫酸软骨素（CS）是一种存在于细胞外基质中的天然糖胺聚糖，由d -葡萄糖醛酸与n -乙酰半乳糖胺的1-3键形成。在软骨细胞中，CS减少白细胞介素-1p （IL-1p）诱导的p38丝裂原活化蛋白激酶（p38MAPK）和信号调节激酶1/2 （Erk1/2）磷酸化的增加，减少核因子- kb （NF-kB）核易位，从而减少促炎细胞因子IL-1p和TNF-a的形成，以及促炎酶，如磷脂酶A2 （PLA2）、环氧化酶2 （COX-2）和一氧化氮合酶2 （NOS-2）。CS的作用机制解释了其对软骨、滑膜和软骨下骨的有益作用。另一方面，在体内，口服CS可阻止肝脏NF-κB核易位，提示全身CS可能在关节外的许多组织中引起抗炎作用。有初步证据表明，在人类中，CS可能有益于其他炎症是重要标志的疾病，如牛皮癣和动脉粥样硬化。文献综述表明，CS也可能对其他炎症和/或自身免疫性疾病的治疗感兴趣，如炎症性肠病、中枢神经系统退行性疾病和中风、多发性硬化症和其他自身免疫性疾病。
Chondroitin sulphate (CS) is a natural glycosaminoglycan present in the extracellular matrix and is formed by the 1–3 linkage of D-glucuronic acid to N-acetylgalactosamine. In chondrocytes, CS diminishes interleukin-1 p (IL-1p)-induced increases in p38 mitogen-activated protein kinase (p38MAPK) and signal-regulated kinase 1/2 (Erk1/2) phosphorylation, and decreases nuclear factor-KB (NF-kB) nuclear translocation and as a consequence, reduces the formation of pro-inflammatory cytokines, IL-1 p and TNF-a, and pro-inflammatory enzymes, such as phospholipase A2 (PLA2), cyclooxygenase 2 (COX-2) and nitric oxide synthase-2 (NOS-2). The mechanism of action of CS explains its beneficial effect on the cartilage, synovial membrane and subchondral bone. On the other hand, in vivo, CS given orally prevents hepatic NF-κB nuclear translocation, suggesting that systemic CS may elicit an anti-inflammatory effect in many tissues besides the articulation. There is preliminary evidence showing that in human beings, CS may be of benefit in other diseases where inflammation is an essential marker, such as psoriasis and atherosclerosis. The review of the literature suggest that CS might also be of interest for the treatment of other diseases with an inflammatory and/or autoimmune character, such as inflammatory bowel disease, degenerative diseases of the central nervous system and stroke, multiple sclerosis and other autoimmune diseases.
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影响因子：
158.5
作者：
Clegg, DO;Reda, DJ;Williams, HJ
通讯作者：
Williams, HJ
影响因子：
7.3
作者：
Amigo, M.;Paya, M.;Terencio, M. C.
通讯作者：
Terencio, M. C.
影响因子：
2.9
作者：
Bright, John J.;Kanakasabai, Saravanan;Chearwae, Wanida;Chakraborty, Sharmistha
通讯作者：
Chakraborty, Sharmistha
影响因子：
4.4
作者：
Bakalash, Sharon;Rolls, Asya;Schwartz, Michal
通讯作者：
Schwartz, Michal
影响因子：
27.4
作者：
BARKER, SA;HAWKINS, CF;HEWINS, M
通讯作者：
HEWINS, M