BRCA1 and p53 tumor suppressor molecules in Alzheimer's disease.
BRCA1 and p53 tumor suppressor molecules in Alzheimer's disease.
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DOI：
10.3390/ijms16022879
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发表时间：
2015-01-28
影响因子：
5.6
通讯作者：
Matsuda S
中科院分区：
文献类型：
--
作者：
Nakanishi A;Minami A;Kitagishi Y;Ogura Y;Matsuda S
肿瘤抑制分子在调节DNA修复、细胞增殖和细胞死亡等过程中发挥关键作用，也是阿尔茨海默病发病的重要过程。阿尔茨海默病是最常见的神经退行性疾病，然而，控制神经元细胞死亡的精确分子事件尚不清楚。近年来，肿瘤抑制分子在调节阿尔茨海默病神经元中的重要作用得到了重视。一般来说，包括阿尔茨海默病在内的神经退行性疾病的发病可以通过使用抗氧化应激的膳食神经保护剂来延缓。研究表明，饮食中的抗氧化剂在降低疾病风险和减缓疾病进展方面也对大脑健康有益。我们总结饮食调节治疗阿尔茨海默病的研究进展，重点关注其对BRCA1和p53肿瘤抑制因子表达的调节作用，为该领域的进一步治疗研究提供支持。
Tumor suppressor molecules play a pivotal role in regulating DNA repair, cell proliferation, and cell death, which are also important processes in the pathogenesis of Alzheimer’s disease. Alzheimer’s disease is the most common neurodegenerative disorder, however, the precise molecular events that control the death of neuronal cells are unclear. Recently, a fundamental role for tumor suppressor molecules in regulating neurons in Alzheimer’s disease was highlighted. Generally, onset of neurodegenerative diseases including Alzheimer’s disease may be delayed with use of dietary neuro-protective agents against oxidative stresses. Studies suggest that dietary antioxidants are also beneficial for brain health in reducing disease-risk and in slowing down disease-progression. We summarize research advances in dietary regulation for the treatment of Alzheimer’s disease with a focus on its modulatory roles in BRCA1 and p53 tumor suppressor expression, in support of further therapeutic research in this field.
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