Human T cell activation. I. Monocyte-independent activation and proliferation induced by anti-T3 monoclonal antibodies in the presence of tumor promoter 12-o-tetradecanoyl phorbol-13 acetate
Human T cell activation. I. Monocyte-independent activation and proliferation induced by anti-T3 monoclonal antibodies in the presence of tumor promoter 12-o-tetradecanoyl phorbol-13 acetate
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人类 T 细胞激活。
DOI：
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发表时间：
1985
影响因子：
15.3
通讯作者：
S. Fu
中科院分区：
文献类型：
--
作者：
T. Hara;S. Fu
Three monoclonal antibodies (mAb), of IgG1, IgG2a, and IgM isotypes, raised against the T3 complex, were used to probe the activation of human T cells. The IgM antibody 235 was not mitogenic for peripheral blood mononuclear cells (PMC). It efficiently blocked the proliferation of PMC induced by T cell mitogens, alloantigens, and soluble antigens. The other two antibodies were mitogenic, and behaved similarly to Leu 4 and OKT3, respectively. In T cell preparations with less than 0.1% monocytes (as assayed by nonspecific esterase staining), all three mAb were not mitogenic. They failed to induce either interleukin 2 (IL-2) receptor expression or IL-2 secretion. Addition of IL-1 failed to collaborate with anti-T3 mAb to induce these T cells to proliferate, but IL-2 enhanced T cell proliferation slightly. Monocyte-depleted T cells, however, proliferated in response to all three anti-T3 mAb, when TPA was added, in a dose-dependent manner. TPA induced a low level of IL-2 receptor expression in monocyte-depleted T cells, without inducing IL-2 secretion. Anti-T3 plus TPA induced a marked enhancement in both quantity and intensity of IL-2 receptor expression. IL-2 secretion was also detected. These results indicate that anti-T3 IgM can deliver an inductive signal despite its blockage of T cell proliferation, and that two signals are necessary and perhaps sufficient to induce human T cell activation and proliferation.
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T3 复合物单克隆抗体诱导淋巴细胞有丝分裂。
影响因子：
4.3
作者：
Tsoukas,CD;Lambris,J;Lotz,M;Valentine,MA;Vaughan,JH;Carson,DA
通讯作者：
Carson,DA
完整 IgG 的 Fc 部分可阻断抗 T3 对人 PBMC 的刺激。
DOI：
--
发表时间：
1984
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Looney,RJ;Abraham,GN
通讯作者：
Abraham,GN
阿尔茨海默型老年痴呆症中的神经原纤维缠结与波形蛋白类中间丝共享抗原决定簇。
DOI：
--
发表时间：
1983
期刊：
The American journal of pathology
影响因子：
--
作者：
Yen,SH;Gaskin,F;Fu,SM
通讯作者：
Fu,SM
影响因子：
4.4
作者：
James P. Allison;Bradley W. McIntyre;D. Bloch
通讯作者：
James P. Allison;Bradley W. McIntyre;D. Bloch
泛 T 单克隆抗体（抗 Leu 4）诱导人 T 淋巴细胞增殖：反应的异质性是单核细胞的功能。
DOI：
--
发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kaneoka,H;Perez-Rojas,G;Sasasuki,T;Benike,CJ;Engleman,EG
通讯作者：
Engleman,EG