Giardia duodenalis in Ugandan Children Aged 9-36 Months in Kampala, Uganda: Prevalence and Associated Factors.
Giardia duodenalis in Ugandan Children Aged 9-36 Months in Kampala, Uganda: Prevalence and Associated Factors.
复制标题
DOI：
10.4269/ajtmh.22-0436
复制
发表时间：
2023-07-05
期刊：
影响因子：
--
通讯作者：
Tumwine JK
中科院分区：
文献类型：
--
作者：
Ndeezi G;Mor SM;Ascolillo LR;Tasimwa HB;Nakato R;Kayondo LN;Tzipori S;Mukunya D;Griffiths JK;Tumwine JK
十二指肠贾第鞭毛虫是一种全球常见的胃肠道病原体，与儿童生长障碍有关。大多数研究都是在学龄儿童中进行的，学龄前儿童的数据很少。我们确定了9-36个月大的儿童中十二指肠球虫感染的患病率和相关因素，这些儿童在穆拉戈医院就诊时出现腹泻或咳嗽。记录人口统计和社会经济特征、动物饲养、病史和体检结果。用实时定量聚合酶链式反应(QPCR)检测粪便中的十二指肠球虫，其他检测包括粪便显微镜检查和隐孢子虫的qPCR检测。十二指肠球虫总感染率为6.7%(214/3173)。腹泻儿童患病率为6.9%(133/1,923)，以咳嗽为主要症状的患病率为6.5%(81/1,250)。214例十二指肠球虫感染患儿中，19例(8.9%)合并隐孢子虫感染。年龄较大的儿童(25-36个月)更容易患十二指肠球虫感染(调整后的优势比[AOR]：2.93，95%CI：1.93-4.43)。使用未改进的厕所(AOR：1.38，95%CI：1.04-1.83)和雨季(AOR：1.33，95%CI：1.00-1.77)与感染增加有关。其他与感染相关的因素有反复腹泻(AOR：2.46，95%CI：1.64~3.70)和排粘液便(AOR：2.25，95%CI：1.08~4.66)。在家里养反刍动物也与感染有关(AOR：1.83，95%CI：1.20-2.79)。在乌干达坎帕拉，9-36个月大的15名腹泻或咳嗽的儿童中有1人感染了十二指肠贾第鞭毛虫。在这种情况下，需要进一步的研究来阐明十二指肠球虫感染的人畜共患病意义。
Giardia duodenalis is a common gastrointestinal pathogen globally that has been associated with growth failure in children. Most of the studies have been done in school-age children, and there is a paucity of data in pre-school children. We determined the prevalence and factors associated with G. duodenalis infection in children aged 9–36 months presenting to Mulago Hospital with diarrhea or cough. Demographic and socio-economic characteristics, animal ownership, medical history, and physical examination findings were recorded. Stool was tested for G. duodenalis using real-time quantitative polymerase chain reaction (qPCR), and additional tests included stool microscopy and qPCR for Cryptosporidium. The overall prevalence of G. duodenalis infection was 6.7% (214/3,173). In children with diarrhea the prevalence was 6.9% (133/1,923), whereas it was 6.5% (81/1,250) in those with cough as the main symptom. Of 214 children with G. duodenalis infection, 19 (8.9%) were co-infected with Cryptosporidium. Older children (25–36 months) were more likely to have G. duodenalis infection (adjusted odds ratio [aOR]: 2.93, 95% CI: 1.93–4.43). Use of an unimproved toilet (aOR: 1.38, 95% CI: 1.04–1.83) and the wet season (aOR: 1.33, 95% CI: 1.00–1.77) were associated with increased infection. Other factors associated with infection were recurrent diarrhea (aOR: 2.46, 95% CI: 1.64–3.70) and passing of mucoid stool (aOR: 2.25, 95% CI: 1.08–4.66). Having a ruminant at the homestead was also associated with infection (aOR: 1.83, 95% CI: 1.20–2.79). Giardia duodenalis infection occurred in 1 of 15 children aged 9–36 months with diarrhea or cough in Kampala, Uganda. Further studies are needed to clarify the zoonotic significance of G. duodenalis infection in this setting.
登录
查看更多内容
DOI：
10.1590/s0036-46652009000300006
发表时间：
2009-06-01
期刊：
Revista do Instituto de Medicina Tropical de São Paulo
影响因子：
--
作者：
Botero-Garcés, Jorge H.;García-Montoya, Gisela M.;Álvarez-Uribe, Martha C.
通讯作者：
Álvarez-Uribe, Martha C.
DOI：
10.1093/cid/cis762
发表时间：
2012-12
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Muhsen K;Levine MM
通讯作者：
Levine MM
影响因子：
3.8
作者：
Tellevik MG;Moyo SJ;Blomberg B;Hjøllo T;Maselle SY;Langeland N;Hanevik K
通讯作者：
Hanevik K
影响因子：
2
作者：
Muhsen, Khitam;Cohen, Dani;Levine, Myron M.
通讯作者：
Levine, Myron M.
影响因子：
7.1
作者：
Platts-Mills, James A.;Taniuchi, Mami;Ahmed, Tahmeed
通讯作者：
Ahmed, Tahmeed