Ontogeny of congenital anomalies of the kidney and urinary tract, CAKUT
Ontogeny of congenital anomalies of the kidney and urinary tract, CAKUT
复制标题
肾脏和泌尿道先天性异常的个体发育，CAKUT
作者：
Y. Miyazaki;I. Ichikawa
最初输尿管的异位芽殖从沃尔夫管是导致许多先天性肾和尿路异常（CAKUT）的第一个体性失误。异位导致肾发育不全、输尿管膀胱口异位、尿流出梗阻和/或反流。最近对几种突变小鼠模型的研究证实，异位输尿管萌芽确实发生在CAKUT形成之前。通常，参与输尿管出芽位置导航的基因也调节肾脏和其他泌尿道系统的后期个体形成过程。由于这些基因通过其独特的细胞功能调节排泄系统许多部分的形态发生，因此这些基因的这些附加功能构成了CAKUT广谱的基础，例如多囊性发育不良肾、巨量肾和闭锁输尿管。
Ectopic budding of the initial ureter from the Wolffian duct is the first ontogenic misstep that leads to many congenital anomalies of the kidney and urinary tract (CAKUT). The ectopia results in hypoplastic kidney, ectopia of ureterovesical orifice, urinary outflow obstruction and/or reflux. Recent studies on several mutant mouse models verified that ectopic ureteric budding indeed occurs prior to the formation of CAKUT. Often, the genes involved in navigating the site of ureteric budding also regulate later ontogenic processes of the kidney and other urinary tract systems. These additional functions of the genes underlie the wide spectrum of CAKUT, for example multicystic dysplastic kidney, megaureter and atretic ureter, because the genes regulate the morphogenesis of the many portions of the excretory system through their distinctive cellular functions.
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影响因子：
10.5
作者：
Lawson, KA;Dunn, NR;Hogan, BLM
通讯作者：
Hogan, BLM
影响因子：
4.6
作者：
A. Schuchardt;V. D’Agati;V. Pachnis;F. Costantini
通讯作者：
A. Schuchardt;V. D’Agati;V. Pachnis;F. Costantini
影响因子：
4.4
作者：
KELLER, SA;JONES, JM;MEISLER, MH
通讯作者：
MEISLER, MH
影响因子：
2.7
作者：
Dunn, NR;Winnier, GE;Hogan, BLM
通讯作者：
Hogan, BLM
影响因子：
15.9
作者：
Miyazaki, Y;Oshima, K;Ichikawa, I
通讯作者：
Ichikawa, I