A user's guide to the encyclopedia of DNA elements (ENCODE).
A user's guide to the encyclopedia of DNA elements (ENCODE).
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DOI：
10.1371/journal.pbio.1001046
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发表时间：
2011-04
期刊：
影响因子：
9.8
通讯作者：
ENCODE Project Consortium
中科院分区：
文献类型：
--
作者：
ENCODE Project Consortium
DNA元素百科全书（ENCODE）项目的使命是使科学和医学界能够解释人类基因组序列，并将其应用于了解人类生物学和改善健康。ENCODE联盟正在整合多种技术和方法，共同努力发现和定义人类基因组中编码的功能元件，包括基因、转录本和转录调控区，以及它们伴随的染色质状态和DNA甲基化模式。在这一过程中，实施了确保高质量数据的标准，并开发了新的算法以促进分析。数据和得出的结果通过一个可免费查阅的数据库提供。在这里，我们提供了一个项目的概述和它正在产生的资源，并说明了应用ENCODE数据来解释人类基因组。DNA元素百科全书（Encyclopedia of DNA Elements，ENCODE）项目的创建是为了使科学和医学界能够解释人类基因组序列，并利用它来了解人类生物学和改善健康。ENCODE Consortium是一个由来自世界各地的科学家组成的大型组织，它使用各种实验方法来识别和描述30亿碱基对人类基因组中对功能至关重要的区域。使用实验，计算和统计分析，我们的目的是发现和描述基因，转录本和转录调控区，以及与基因组中的调控区相互作用的DNA结合蛋白，包括转录因子，不同版本的组蛋白和其他标记物，以及定义各种细胞类型中基因组状态的DNA甲基化模式。ENCODE项目为每种实验类型制定了标准，以确保高质量，可重复的数据和新颖的算法，以促进分析。所有数据和得出的结果都可通过一个免费访问的数据库获得。本文概述了整个项目及其产生的资源，并举例说明了ENCODE数据作为用户指南的应用，以促进人类基因组的解释。
The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome. The Encyclopedia of DNA Elements (ENCODE) Project was created to enable the scientific and medical communities to interpret the human genome sequence and to use it to understand human biology and improve health. The ENCODE Consortium, a large group of scientists from around the world, uses a variety of experimental methods to identify and describe the regions of the 3 billion base-pair human genome that are important for function. Using experimental, computational, and statistical analyses, we aimed to discover and describe genes, transcripts, and transcriptional regulatory regions, as well as DNA binding proteins that interact with regulatory regions in the genome, including transcription factors, different versions of histones and other markers, and DNA methylation patterns that define states of the genome in various cell types. The ENCODE Project has developed standards for each experiment type to ensure high-quality, reproducible data and novel algorithms to facilitate analysis. All data and derived results are made available through a freely accessible database. This article provides an overview of the complete project and the resources it is generating, as well as examples to illustrate the application of ENCODE data as a user's guide to facilitate the interpretation of the human genome.
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影响因子：
4.5
作者：
Collins PJ;Kobayashi Y;Nguyen L;Trinklein ND;Myers RM
通讯作者：
Myers RM
影响因子：
7
作者：
Dostie, Josee;Richmond, Todd A.;Dekker, Job
通讯作者：
Dekker, Job
影响因子：
64.8
作者：
Collins, FS;Green, ED;Guyer, MS
通讯作者：
Guyer, MS
DOI：
10.1101/sqb.2003.68.245
发表时间：
2003-01-01
期刊：
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY
影响因子：
--
作者：
Chiaromonte, F;Weber, RJ;Haussler, D
通讯作者：
Haussler, D
影响因子：
56.9
作者：
Dekker, J;Rippe, K;Kleckner, N
通讯作者：
Kleckner, N