Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms.

Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms.
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DOI:
10.1016/j.tranon.2021.101224
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发表时间:
2021-12
影响因子:
5
通讯作者:
Brandi G
Brandi G
中科院分区:
医学3区
文献类型:
--
作者:
Frega G;Kepp O;Turchetti D;Rizzo A;Pantaleo MA;Brandi G

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癌细胞的遗传背景和抗原景观在免疫疗法的反应中起着关键作用。高肿瘤抗原性,加上一种特殊类型的细胞死亡(即免疫原性细胞死亡(ICD))可能诱导的佐剂性增加,可以促进对免疫原性治疗的反应。妊娠滋养细胞肿瘤(GTN)由于其独特的基因组组成,在肿瘤学领域是一种独一无二的癌症。GTN的预后明显优于非妊娠滋养细胞肿瘤(nGTN)。由于其独特的基因遗传,GTN可能构成免疫肿瘤学领域的单一原型。
The genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely immunogenic cell death (ICD), could foster the response to immunogenic therapies. The gestational trophoblastic neoplasm (GTN) is a one-of-a-kind cancer in the oncological landscape due to its exclusive genomic makeup. The prognosis of GTN is significantly better than non-gestational trophoblastic neoplasm (nGTN). Due to its peculiar genetic inheritance, GTN potentially constitutes a singular archetype in the immuno-oncological field.
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