Improvement of endometrial biopsy over transvaginal ultrasound alone for endometrial surveillance in women with Lynch syndrome.
Improvement of endometrial biopsy over transvaginal ultrasound alone for endometrial surveillance in women with Lynch syndrome.
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DOI：
10.1007/s10689-009-9252-x
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发表时间：
2009
期刊：
影响因子：
2.2
通讯作者：
de Hullu, Joanne A.
中科院分区：
文献类型：
--
作者：
Gerritzen, Lotte H. M.;Hoogerbrugge, Nicoline;Oei, Angele L. M.;Nagengast, Fokko M.;van Ham, Maaike A. P. C.;Massuger, Leon F. A. G.;de Hullu, Joanne A.
遗传性非息肉病性结直肠癌（HNPCC）的妇女，每年的妇科监测已被推荐，因为发展子宫内膜癌和卵巢癌的终生风险增加。本研究的目的是评估妇科监测子宫内膜癌和卵巢癌的有效性。包括来自符合修订后的阿姆斯特丹HNPCC标准的家庭的妇女，或者在一个错配修复基因中显示出已证实的突变的妇女。每年进行妇科监测（经阴道超声（TVU）和CA 125评估）。从2006年1月开始，纳入常规子宫内膜取样。对总共100名妇女进行了285次监测访问。其中，在64次访问中，进行了常规子宫内膜取样：诊断为三个不典型增生和一个子宫内膜癌。这明显多于不典型增生和两个子宫内膜癌后，发现28个样本，因为在221次访问的异常监测结果。没有间隔癌。在卵巢监测中诊断出一例IIIC期浸润性卵巢癌。子宫内膜监测与常规子宫内膜采样的妇女与HNPCC是更有效的诊断子宫内膜（前）恶性肿瘤比TVU。卵巢监测不能诊断早期卵巢癌。HNPCC的预防性子宫切除术应限于因其他原因进行腹部手术的妇女，以及那些风险特别高的妇女，如MSH 6突变携带者和/或有多个亲属患有子宫内膜癌的妇女。
In women with hereditary non polyposis colorectal carcinoma (HNPCC) an annual gynaecological surveillance has been recommended because of an increased lifetime risk of developing endometrial and ovarian carcinoma. The aim of this study was to assess the efficacy of gynaecological surveillance with regard to endometrial and ovarian carcinoma. Included were women from families that fulfilled the revised Amsterdam criteria for HNPCC or who showed a proven mutation in one of the mismatch repair genes. An annual gynaecological surveillance was performed (transvaginal ultrasound (TVU) and CA 125 assessment). From January 2006 on, routine endometrial sampling was included. In a total number of 100 women 285 surveillance visits were performed. Among these, in 64 visits routine endometrial samplings were performed: three atypical hyperplasias and one endometrial carcinoma were diagnosed. This was significantly more than the atypical hyperplasia and two endometrial carcinomas that were detected after 28 samples performed because of abnormal surveillance results in 221 visits. There were no interval carcinomas. One invasive ovarian carcinoma stage IIIC was diagnosed at ovarian surveillance. Endometrial surveillance with routine endometrial sampling in women with HNPCC is more efficient in diagnosing endometrial (pre)malignancies than TVU only. Ovarian surveillance is not capable of diagnosing early stage ovarian carcinoma. Prophylactic hysterectomy in HNPCC should be restricted to women in whom abdominal surgery for other reasons is performed and to those with particularly increased risk such as MSH6 mutation carriers and/or women with multiple relatives with endometrial carcinoma.
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影响因子：
4.7
作者：
Rijcken, FEM;Mourits, MJE;van der Zee, AGJ
通讯作者：
van der Zee, AGJ
影响因子：
2.2
作者：
Lu, Karen H.
通讯作者：
Lu, Karen H.
影响因子：
--
作者：
LYNCH, HT;SHAW, MW;KRUSH, AJ
通讯作者：
KRUSH, AJ
影响因子：
6.1
作者：
Mäkinen, J;Johansson, J;Sjöberg, J
通讯作者：
Sjöberg, J
影响因子：
29.4
作者：
Vasen, HFA;Watson, P;Lynch, HT
通讯作者：
Lynch, HT